Personalized prediction for a 68 year old man who takes Lactulose, Pregabalin, Sertraline Hydrochloride, Clarithromycin, Omeprazole (an AI-powered real world drug study)

Summary:

This is a personalized prediction of potential side effects and undetected conditions for up to one year, if you would have adverse effects. The study is created by eHealthMe based on data from the FDA.

What are the drugs?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,958 Lactulose users. Check the latest studies of Lactulose.
Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,049 Pregabalin users. Check the latest studies of Pregabalin.
Sertraline hydrochloride has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 28,191 Sertraline hydrochloride users. Check the latest studies of Sertraline hydrochloride.
Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,042 Clarithromycin users. Check the latest studies of Clarithromycin.
Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,577 Omeprazole users. Check the latest studies of Omeprazole.

What are the conditions?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 867 drugs and 1,446 conditions by eHealthMe. Check the latest studies of Major depression.
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,155 drugs and 1,413 conditions by eHealthMe. Check the latest studies of Sciatica.
Chronic sinus infection is found to be associated with 1,267 drugs and 745 conditions by eHealthMe. Check the latest studies of Chronic sinus infection.
Duodenitis (inflammation of the duodenum) is found to be associated with 742 drugs and 637 conditions by eHealthMe. Check the latest studies of Duodenitis.
Encephalitis (inflammation of the brain) is found to be associated with 733 drugs and 839 conditions by eHealthMe. Check the latest studies of Encephalitis.

Potential side effects:

Acute prerenal failure

13.51% for males aged 68 (±5) who have duodenitis

Altered state of consciousness

5.16% for males aged 68 (±5) who have duodenitis and encephalitis

Anaemia

6.78% for males aged 68 (±5) who have sciatica and duodenitis
5.8% for males aged 68 (±5) who have sciatica and encephalitis
5.63% for males aged 68 (±5) who have chronic sinus infection and sciatica

Confusional state

5.08% for males aged 68 (±5) who have encephalitis

Convulsion

5.16% for males aged 68 (±5) who have duodenitis and encephalitis

Crystal nephropathy

5.16% for males aged 68 (±5) who have duodenitis and encephalitis

Death

5.08% for males aged 68 (±5) who take lactulose
5.08% for males aged 68 (±5) who take pregabalin
5.08% for males aged 68 (±5) who take sertraline hydrochloride
5.08% for males aged 68 (±5) who take clarithromycin
5.08% for males aged 68 (±5) who take omeprazole

Dehydration

16.22% for males aged 68 (±5) who have duodenitis

Diarrhea

7.58% for males aged 68 (±5) who have chronic sinus infection and duodenitis
7.1% for males aged 68 (±5) who have duodenitis and encephalitis
6.34% for males aged 68 (±5) who have sciatica and duodenitis

Dizziness

5.6% for males aged 68 (±5) who have sciatica and duodenitis
5.4% for males aged 68 (±5) who have sciatica and encephalitis
5.38% for males aged 68 (±5) who have sciatica and major depression

Drug ineffective

9.88% for males aged 68 (±5) who have sciatica and encephalitis
9.29% for males aged 68 (±5) who have sciatica and duodenitis
9.26% for males aged 68 (±5) who have sciatica and major depression
9.2% for males aged 68 (±5) who have major depression and encephalitis
9.03% for males aged 68 (±5) who have duodenitis and encephalitis
8.71% for males aged 68 (±5) who have duodenitis and major depression
8.13% for males aged 68 (±5) who have chronic sinus infection and sciatica
7.86% for males aged 68 (±5) who have chronic sinus infection and major depression
5.73% for males aged 68 (±5) who have chronic sinus infection and encephalitis

Drug-induced liver injury

5.81% for males aged 68 (±5) who have duodenitis and encephalitis

Duodenitis

13.51% for males aged 68 (±5) who have duodenitis

Dyspnea

6.06% for males aged 68 (±5) who have chronic sinus infection and duodenitis

Encephalitis

8.39% for males aged 68 (±5) who have duodenitis and encephalitis

Fatigue

5.16% for males aged 68 (±5) who have duodenitis and encephalitis

Fever

6.09% for males aged 68 (±5) who have chronic sinus infection and encephalitis
6.06% for males aged 68 (±5) who have chronic sinus infection and duodenitis
5.81% for males aged 68 (±5) who have duodenitis and encephalitis

Hypomagnesaemia

5.16% for males aged 68 (±5) who have duodenitis and encephalitis

Hypotension

5.81% for males aged 68 (±5) who have duodenitis and encephalitis

Nausea and vomiting

6.45% for males aged 68 (±5) who have duodenitis and encephalitis
5.16% for males aged 68 (±5) who have sciatica and duodenitis
5.05% for males aged 68 (±5) who have chronic sinus infection and duodenitis

Pneumonia

11.62% for males aged 68 (±5) who have chronic sinus infection and duodenitis
7.89% for males aged 68 (±5) who have chronic sinus infection and encephalitis
5.13% for males aged 68 (±5) who have chronic sinus infection and sciatica

Rashes

5.08% for males aged 68 (±5) who have encephalitis

Weight decreased

5.59% for males aged 68 (±5) who have chronic sinus infection

Potential co-existing conditions:

Acute disseminated encephalomyelitis

5.93% for males aged 68 (±5) who have encephalitis

Asthma

15.66% for males aged 68 (±5) who have chronic sinus infection and duodenitis
11.11% for males aged 68 (±5) who have chronic sinus infection and encephalitis

Atrial fibrillation/flutter

5.05% for males aged 68 (±5) who have chronic sinus infection and duodenitis

Back pain

12.39% for males aged 68 (±5) who have sciatica and duodenitis
11.07% for males aged 68 (±5) who have sciatica and encephalitis
10.75% for males aged 68 (±5) who have chronic sinus infection and sciatica
6.04% for males aged 68 (±5) who have sciatica and major depression

Barrett's oesophagus

18.92% for males aged 68 (±5) who have duodenitis

Bronchiectasis

5.05% for males aged 68 (±5) who have chronic sinus infection and duodenitis

Convulsion

5.08% for males aged 68 (±5) who have encephalitis

Diabetes

5.75% for males aged 68 (±5) who have sciatica and duodenitis
5.56% for males aged 68 (±5) who have chronic sinus infection and duodenitis
5.0% for males aged 68 (±5) who have chronic sinus infection and sciatica

Duodenitis

23.87% for males aged 68 (±5) who have duodenitis and encephalitis
18.69% for males aged 68 (±5) who have chronic sinus infection and duodenitis
5.46% for males aged 68 (±5) who have sciatica and duodenitis

Encephalitis

76.13% for males aged 68 (±5) who have duodenitis and encephalitis
42.29% for males aged 68 (±5) who have chronic sinus infection and encephalitis
15.55% for males aged 68 (±5) who have sciatica and encephalitis
11.8% for males aged 68 (±5) who have major depression and encephalitis

Encephalomyelitis

5.08% for males aged 68 (±5) who have encephalitis

Gastritis

5.16% for males aged 68 (±5) who have duodenitis and encephalitis

Glioblastoma

5.93% for males aged 68 (±5) who have encephalitis

High blood cholesterol

12.0% for males aged 68 (±5) who have chronic sinus infection and sciatica
11.65% for males aged 68 (±5) who have sciatica and duodenitis
10.41% for males aged 68 (±5) who have sciatica and encephalitis
8.59% for males aged 68 (±5) who have chronic sinus infection and duodenitis
7.22% for males aged 68 (±5) who have sciatica and major depression
6.09% for males aged 68 (±5) who have chronic sinus infection and encephalitis

High blood pressure

19.7% for males aged 68 (±5) who have chronic sinus infection and duodenitis
18.13% for males aged 68 (±5) who have chronic sinus infection and sciatica
17.7% for males aged 68 (±5) who have sciatica and duodenitis
15.15% for males aged 68 (±5) who have sciatica and encephalitis
13.39% for males aged 68 (±5) who have sciatica and major depression
12.19% for males aged 68 (±5) who have chronic sinus infection and encephalitis
11.79% for males aged 68 (±5) who have chronic sinus infection and major depression
10.45% for males aged 68 (±5) who have duodenitis and major depression
9.1% for males aged 68 (±5) who have major depression and encephalitis
5.59% for males aged 68 (±5) who take lactulose
5.59% for males aged 68 (±5) who take pregabalin
5.59% for males aged 68 (±5) who take sertraline hydrochloride
5.59% for males aged 68 (±5) who take clarithromycin
5.59% for males aged 68 (±5) who take omeprazole

Hyperlipidaemia

16.22% for males aged 68 (±5) who have duodenitis

Hypersensitivity

5.05% for males aged 68 (±5) who have chronic sinus infection and duodenitis

Hypogammaglobulinaemia

5.59% for males aged 68 (±5) who have chronic sinus infection

Insomnia

10.1% for males aged 68 (±5) who have chronic sinus infection and duodenitis
7.0% for males aged 68 (±5) who have chronic sinus infection and major depression
6.86% for males aged 68 (±5) who have duodenitis and major depression
5.8% for males aged 68 (±5) who have major depression and encephalitis
5.38% for males aged 68 (±5) who have chronic sinus infection and encephalitis
5.06% for males aged 68 (±5) who have sciatica and major depression

Major depression

95.97% for males aged 68 (±5) who have duodenitis and major depression
88.2% for males aged 68 (±5) who have major depression and encephalitis
84.56% for males aged 68 (±5) who have chronic sinus infection and major depression
57.91% for males aged 68 (±5) who have sciatica and major depression

Multiple myeloma

5.19% for males aged 68 (±5) who take lactulose
5.19% for males aged 68 (±5) who take pregabalin
5.19% for males aged 68 (±5) who take sertraline hydrochloride
5.19% for males aged 68 (±5) who take clarithromycin
5.19% for males aged 68 (±5) who take omeprazole

Nasal polyps

9.09% for males aged 68 (±5) who have chronic sinus infection and duodenitis
6.45% for males aged 68 (±5) who have chronic sinus infection and encephalitis

Nausea

13.51% for males aged 68 (±5) who have duodenitis

Neuropathy peripheral

5.05% for males aged 68 (±5) who have chronic sinus infection and duodenitis

Sciatica

94.54% for males aged 68 (±5) who have sciatica and duodenitis
84.45% for males aged 68 (±5) who have sciatica and encephalitis
80.13% for males aged 68 (±5) who have chronic sinus infection and sciatica
42.09% for males aged 68 (±5) who have sciatica and major depression

Sinusitis - chronic

81.31% for males aged 68 (±5) who have chronic sinus infection and duodenitis
57.71% for males aged 68 (±5) who have chronic sinus infection and encephalitis
20.13% for males aged 68 (±5) who have chronic sinus infection and sciatica
15.44% for males aged 68 (±5) who have chronic sinus infection and major depression

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

How the study uses the data?

The study is based on gender, age, active ingredients of any drugs used, and more. Other drugs that have the same active ingredients (e.g. generic drugs) are considered.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

Related publications that referenced our studies

de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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