Personalized prediction for a 57 year old woman who takes Melatonin, Estrogel, Levothyroxine Thyroid, Progesterone (an AI-powered real world drug study)
Summary:
This is a personalized prediction of potential side effects and undetected conditions for up to one year, if you would have adverse effects. The study is created by eHealthMe based on data from the FDA.
On Sep, 24, 2025, 6,964,716 related reports were analyzed:

What are the drugs?
- Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,194 Melatonin users. Check the latest studies of Melatonin.
- Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,917 Estrogel users. Check the latest studies of Estrogel.
- Levothyroxine thyroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 4,032 Levothyroxine thyroid users. Check the latest studies of Levothyroxine thyroid.
- Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,010 Progesterone users. Check the latest studies of Progesterone.
What are the conditions?
- Jet lag (a temporary disruption of bodily rhythms due to travelling on high speed) is found to be associated with 4 drugs by eHealthMe. Check the latest studies of Jet lag.
- Sleep issues (sleep problems) is found to be associated with 4,365 drugs and 5,332 conditions by eHealthMe. Check the latest studies of Sleep issues.
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,626 drugs and 2,558 conditions by eHealthMe. Check the latest studies of Hypothyroidism.
- Hot flashes is found to be associated with 2,563 drugs and 2,370 conditions by eHealthMe. Check the latest studies of Hot flashes.
Potential side effects:
- 6.55% for females aged 57 (±5) who have hypothyroidism and jet lag
- 6.38% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 5.88% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 5.02% for females aged 57 (±5) who have hot flashes and jet lag
- 7.35% for females aged 57 (±5) who have hypothyroidism and jet lag
- 7.0% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 6.49% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 5.23% for females aged 57 (±5) who have sleep issues and jet lag
- 5.12% for females aged 57 (±5) who have hot flashes and sleep issues
- 16.0% for females aged 57 (±5) who have hot flashes and jet lag
- 12.62% for females aged 57 (±5) who have hot flashes and sleep issues
- 11.92% for females aged 57 (±5) who have sleep issues and jet lag
- 9.25% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 8.23% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 7.04% for females aged 57 (±5) who have hypothyroidism and jet lag
- 6.17% for females aged 57 (±5) who take melatonin
- 6.17% for females aged 57 (±5) who take progesterone
- 6.17% for females aged 57 (±5) who take estrogel
- 6.17% for females aged 57 (±5) who take levothyroxine thyroid
- 5.5% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 5.39% for females aged 57 (±5) who have hypothyroidism and jet lag
- 5.08% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 5.0% for females aged 57 (±5) who have sleep issues and jet lag
- 11.4% for females aged 57 (±5) who have hypothyroidism and jet lag
- 10.99% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 9.55% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 7.89% for females aged 57 (±5) who have hot flashes and jet lag
- 7.29% for females aged 57 (±5) who have hot flashes and sleep issues
- 7.15% for females aged 57 (±5) who have sleep issues and jet lag
- 6.13% for females aged 57 (±5) who take levothyroxine thyroid
- 6.13% for females aged 57 (±5) who take progesterone
- 6.13% for females aged 57 (±5) who take melatonin
- 6.13% for females aged 57 (±5) who take estrogel
- 9.04% for females aged 57 (±5) who have hypothyroidism and jet lag
- 8.72% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 8.27% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 7.15% for females aged 57 (±5) who have sleep issues and jet lag
- 7.12% for females aged 57 (±5) who have hot flashes and sleep issues
- 6.85% for females aged 57 (±5) who have hot flashes and jet lag
- 5.27% for females aged 57 (±5) who take levothyroxine thyroid
- 5.27% for females aged 57 (±5) who take progesterone
- 5.27% for females aged 57 (±5) who take melatonin
- 5.27% for females aged 57 (±5) who take estrogel
- 9.34% for females aged 57 (±5) who have hot flashes and jet lag
- 9.75% for females aged 57 (±5) who have sleep issues and jet lag
- 9.29% for females aged 57 (±5) who have hot flashes and sleep issues
- 7.36% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 6.78% for females aged 57 (±5) who have hot flashes and jet lag
- 5.55% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 5.35% for females aged 57 (±5) who have hypothyroidism and jet lag
- 6.28% for females aged 57 (±5) who have hypothyroidism and jet lag
- 6.09% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 5.48% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 5.17% for females aged 57 (±5) who have hot flashes and jet lag
- 5.13% for females aged 57 (±5) who have hypothyroidism and jet lag
- 8.19% for females aged 57 (±5) who have hypothyroidism and jet lag
- 8.06% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 7.93% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 7.43% for females aged 57 (±5) who have sleep issues and jet lag
- 7.42% for females aged 57 (±5) who have hot flashes and sleep issues
- 7.2% for females aged 57 (±5) who have hot flashes and jet lag
- 6.44% for females aged 57 (±5) who take melatonin
- 6.44% for females aged 57 (±5) who take progesterone
- 6.44% for females aged 57 (±5) who take estrogel
- 6.44% for females aged 57 (±5) who take levothyroxine thyroid
- 7.47% for females aged 57 (±5) who have hot flashes and jet lag
- 6.17% for females aged 57 (±5) who have hot flashes and sleep issues
- 6.16% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 5.98% for females aged 57 (±5) who have hypothyroidism and jet lag
- 5.97% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 5.88% for females aged 57 (±5) who have sleep issues and jet lag
- 5.39% for females aged 57 (±5) who have sleep issues and jet lag
- 5.28% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 5.09% for females aged 57 (±5) who have hot flashes and sleep issues
- 5.06% for females aged 57 (±5) who have hypothyroidism and jet lag
- 6.11% for females aged 57 (±5) who have hypothyroidism and jet lag
- 5.69% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 5.32% for females aged 57 (±5) who have sleep issues and hypothyroidism
Potential co-existing conditions:
- 5.26% for females aged 57 (±5) who have hypothyroidism and jet lag
- 8.27% for females aged 57 (±5) who have sleep issues and jet lag
- 7.12% for females aged 57 (±5) who have hot flashes and sleep issues
- 5.43% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 23.38% for females aged 57 (±5) who have sleep issues and jet lag
- 20.74% for females aged 57 (±5) who have hot flashes and sleep issues
- 18.33% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 15.49% for females aged 57 (±5) who have hypothyroidism and jet lag
- 14.33% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 7.12% for females aged 57 (±5) who have hot flashes and jet lag
- 7.52% for females aged 57 (±5) who have hypothyroidism and jet lag
- 6.88% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 6.61% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 5.8% for females aged 57 (±5) who have sleep issues and jet lag
- 5.32% for females aged 57 (±5) who have hot flashes and sleep issues
- 5.39% for females aged 57 (±5) who have sleep issues and jet lag
- 5.0% for females aged 57 (±5) who have hot flashes and sleep issues
- 12.68% for females aged 57 (±5) who have sleep issues and jet lag
- 11.67% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 11.66% for females aged 57 (±5) who have hypothyroidism and jet lag
- 11.61% for females aged 57 (±5) who have hot flashes and sleep issues
- 10.86% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 6.05% for females aged 57 (±5) who have hot flashes and jet lag
- 13.81% for females aged 57 (±5) who have hypothyroidism and jet lag
- 12.86% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 11.8% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 9.88% for females aged 57 (±5) who have sleep issues and jet lag
- 9.44% for females aged 57 (±5) who have hot flashes and sleep issues
- 7.24% for females aged 57 (±5) who have hot flashes and jet lag
- 26.35% for females aged 57 (±5) who have hypothyroidism and jet lag
- 24.35% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 22.44% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 18.59% for females aged 57 (±5) who have sleep issues and jet lag
- 17.44% for females aged 57 (±5) who have hot flashes and sleep issues
- 11.29% for females aged 57 (±5) who have hot flashes and jet lag
- 100.0% for females aged 57 (±5) who have hot flashes and jet lag
- 16.65% for females aged 57 (±5) who have hot flashes and sleep issues
- 13.48% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 6.58% for females aged 57 (±5) who take melatonin
- 6.58% for females aged 57 (±5) who take estrogel
- 6.58% for females aged 57 (±5) who take levothyroxine thyroid
- 6.58% for females aged 57 (±5) who take progesterone
- 7.96% for females aged 57 (±5) who have sleep issues and jet lag
- 6.96% for females aged 57 (±5) who have hot flashes and sleep issues
- 5.53% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 9.8% for females aged 57 (±5) who have hot flashes and jet lag
- 19.92% for females aged 57 (±5) who have sleep issues and jet lag
- 17.99% for females aged 57 (±5) who have hot flashes and sleep issues
- 15.17% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 12.27% for females aged 57 (±5) who have hypothyroidism and jet lag
- 11.64% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 8.23% for females aged 57 (±5) who have hot flashes and jet lag
- 11.31% for females aged 57 (±5) who take melatonin
- 11.31% for females aged 57 (±5) who take estrogel
- 11.31% for females aged 57 (±5) who take levothyroxine thyroid
- 11.31% for females aged 57 (±5) who take progesterone
- 11.23% for females aged 57 (±5) who have hypothyroidism and jet lag
- 10.5% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 10.02% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 8.84% for females aged 57 (±5) who have sleep issues and jet lag
- 8.29% for females aged 57 (±5) who have hot flashes and sleep issues
- 5.67% for females aged 57 (±5) who have hot flashes and jet lag
- 19.27% for females aged 57 (±5) who have sleep issues and jet lag
- 17.07% for females aged 57 (±5) who have hot flashes and sleep issues
- 12.97% for females aged 57 (±5) who have sleep issues and hypothyroidism
- 8.88% for females aged 57 (±5) who have hypothyroidism and jet lag
- 8.47% for females aged 57 (±5) who have hot flashes and hypothyroidism
- 5.9% for females aged 57 (±5) who have hot flashes and jet lag
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
How the study uses the data?
The study is based on gender, age, active ingredients of any drugs used, and more. Other drugs that have the same active ingredients (e.g. generic drugs) are considered.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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