Accutane and Zestril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accutane (isotretinoin) and Zestril (lisinopril). Common drug interactions include inflammatory bowel disease among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Accutane and Zestril. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

On Aug, 05, 2026

15 people who take Accutane and Zestril together, and have interactions are studied.

What are the common drug interactions of Accutane and Zestril, by gender? *:

female:

Inflammatory bowel disease
Emotional distress
Injury
Chest pain
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Intestinal obstruction
Anxiety
Cough
Hypoaesthesia (reduced sense of touch or sensation)
Sinusitis (inflammation of sinus)

male:

Anxiety
Blood cholesterol increased
Intestinal obstruction
Sinusitis (inflammation of sinus)
Vomiting
Prostatic specific antigen increased
Blood triglycerides increased
Chest pain
Cough
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

What are the common drug interactions of Accutane and Zestril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood triglycerides increased
Gastritis (inflammation of stomach)
Hypoaesthesia facial (reduced sense of touch or sensation on face)
Dry skin
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Vulvovaginal dryness
Anxiety
Chest pain
Cough
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

40-49:

Abdominal discomfort
Chest pain
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fatigue (feeling of tiredness)
Inflammatory bowel disease
Intestinal obstruction

50-59:

Abdominal discomfort
Abscess (pus)
Anaemia of chronic disease
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood creatinine increased
Blood urea increased
Cardiac murmur (an heart sound in valve abnormality)
Cellulitis (infection under the skin)
Cholangitis sclerosing (infection and obstruction of bile duct)

60+:

Emotional distress
Inflammatory bowel disease
Injection site pain
Irritable bowel syndrome
Oesophagitis (inflammation of oesophagus)
Pain in extremity
Pain of skin
Pruritus (severe itching of the skin)
Surgery
Vision blurred

What are the existing conditions these people have? *

Acne Cystic (skin problems that cause pimples): 4 people, 26.67%
Osteoporosis (bones weak and more likely to break): 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Cardiomyopathy (weakening of the heart muscle): 1 person, 6.67%
Breast Cancer: 1 person, 6.67%
Arrhythmias (irregular heartbeat): 1 person, 6.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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