Acetaminophen and codeine phosphate and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate) and Leflunomide (leflunomide). Common drug interactions include psoriasis among females and acute coronary syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and codeine phosphate and Leflunomide. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 10, 2026

34 people who take Acetaminophen and codeine phosphate and Leflunomide together, and have interactions are studied.

Acetaminophen and codeine phosphate and Leflunomide drug interactions.

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Leflunomide, by gender? *:

female:

Psoriasis (immune-mediated disease that affects the skin)
Pulmonary embolism (blockage of the main artery of the lung)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)
Septic shock (shock due to blood infection)
Sputum discoloured
Streptococcal urinary tract infection (a bacterial infection of urinary tract)
Synovial cyst (cyst of joint filled with synovial fluid)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Chest pain
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Guttate psoriasis (a type of psoriasis that looks like small drops on the skin)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Iron deficiency anaemia
Left ventricular failure (left ventricle fails to contract forcefully)

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Leflunomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Dysphonia (speech disorder attributable to a disorder of phonation)
Leukopenia (less number of white blood cells in blood)
Psoriasis (immune-mediated disease that affects the skin)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)
Streptococcal urinary tract infection (a bacterial infection of urinary tract)
Synovial cyst (cyst of joint filled with synovial fluid)
Urinary tract infection
Uterine cyst

50-59:

Blood pressure increased
Body temperature increased
Hot flush (sudden feelings of heat)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone marrow failure
Breast cancer
Cellulitis (infection under the skin)
Chest pain
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Depression

60+:

Acute hepatic failure
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Multi-organ failure (multisystem organ failure)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Chest pain
Angina pectoris (chest pain due to ischemia of the heart muscle)
Drug resistance (reduction in effectiveness of a drug)
Neck pain
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 20.59%
High Blood Cholesterol: 6 people, 17.65%
Gastric Ulcer (stomach ulcer): 6 people, 17.65%
Asthma: 6 people, 17.65%
Stable Angina (a constant chest pain): 5 people, 14.71%
Muscle Spasms (muscle contraction): 4 people, 11.76%
Anaesthesia: 4 people, 11.76%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 8.82%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.88%
Indigestion: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and codeine phosphate and Leflunomide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously