Acetaminophen and codeine phosphate and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate) and Spironolactone (spironolactone). Common drug interactions include oedema peripheral among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and codeine phosphate and Spironolactone. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

On Jul, 13, 2026

88 people who take Acetaminophen and codeine phosphate and Spironolactone together, and have interactions are studied.

Acetaminophen and codeine phosphate and Spironolactone drug interactions.

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Spironolactone, by gender? *:

female:

Oedema peripheral (superficial swelling)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Dry skin
Erythema (redness of the skin)
Hypersensitivity
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Exfoliative rash (scaly red generalized skin rash)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pruritus (severe itching of the skin)

male:

Vomiting
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure
Constipation
Gastric antral vascular ectasia (blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding)
Lower respiratory tract infection
Lymphadenitis (inflammation or enlargement of a lymph node)
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Small cell lung cancer stage unspecified (lung cancer in unknown stage)

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Abdominal pain
Anaemia (lack of blood)
Blood albumin decreased
Constipation
Depression
Disease progression
Fatigue (feeling of tiredness)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
International normalised ratio increased

50-59:

Vomiting
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
White blood cell count increased
Lung neoplasm malignant (cancer tumour of lung)
Gastric disorder (disease of stomach)
Respiratory disorder (respiratory disease)
Syncope (loss of consciousness with an inability to maintain postural tone)
Bone marrow failure
Calciphylaxis (is a syndrome with vascular calcium accumulation)
Cardiac failure

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Haemoglobin decreased
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Dry skin
Erythema (redness of the skin)
Hypersensitivity
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Exfoliative rash (scaly red generalized skin rash)
Petechiae (a small red or purple spot caused by bleeding into the skin)

What are the existing conditions these people have? *

Pneumonia: 33 people, 37.50%
Pulmonary Embolism (blockage of the main artery of the lung): 19 people, 21.59%
Cardiac Failure: 17 people, 19.32%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 16 people, 18.18%
High Blood Cholesterol: 13 people, 14.77%
Constipation: 13 people, 14.77%
Alcohol Withdrawal Syndrome: 12 people, 13.64%
Acute Kidney Failure: 12 people, 13.64%
High Blood Pressure: 11 people, 12.50%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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