Aciphex and Simcor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Simcor (niacin; simvastatin). Common drug interactions include flushing among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Simcor. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

On Jul, 18, 2026

38 people who take Aciphex and Simcor together, and have interactions are studied.

What are the common drug interactions of Aciphex and Simcor, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Skin burning sensation
Feeling hot
Pruritus (severe itching of the skin)
Abdominal pain
Abdominal pain upper
Heart rate increased
Chronic kidney disease
Erythema (redness of the skin)
Renal failure (kidney dysfunction)

male:

Flushing (the warm, red condition of human skin)
Erythema (redness of the skin)
Panic attack
Pruritus (severe itching of the skin)
Rash
Red blood cells urine positive
Skin irritation
Asthma
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Aciphex and Simcor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Pruritus (severe itching of the skin)
Abdominal pain upper
Feeling hot
Flatulence (flatus expelled through the anus)
Haematochezia (passage of stools containing blood)
Heart rate increased
Ill-defined disorder
Flushing (the warm, red condition of human skin)

50-59:

Flushing (the warm, red condition of human skin)
Skin burning sensation
Erythema (redness of the skin)
Rash
Abdominal pain upper
Chest discomfort
Diarrhoea
Drug hypersensitivity
Feeling hot
Headache (pain in head)

60+:

Flushing (the warm, red condition of human skin)
Blood uric acid increased
Skin burning sensation
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Blood pressure increased
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Dizziness

What are the existing conditions these people have? *

High Density Lipoprotein Decreased: 6 people, 15.79%
Low Density Lipoprotein Increased (cholesterol increased in blood): 4 people, 10.53%
High Blood Pressure: 4 people, 10.53%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 7.89%
Pain: 3 people, 7.89%
Oedema (fluid collection in tissue): 3 people, 7.89%
Fever: 3 people, 7.89%
Dyslipidaemia (abnormal amount of lipids): 3 people, 7.89%
Diabetes: 3 people, 7.89%
Depression: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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