Activella and Aspirin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activella (estradiol; norethindrone acetate) and Aspirin (aspirin). Common drug interactions include chronic kidney disease among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Activella and Aspirin. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Aspirin?

Aspirin has active ingredients of aspirin. It is often used in blood clots. eHealthMe is studying from 632,088 Aspirin users. Check the latest studies of Aspirin.

On Jul, 13, 2026

81 people who take Activella and Aspirin together, and have interactions are studied.

Activella and Aspirin drug interactions.

What are the common drug interactions of Activella and Aspirin, by gender? *:

female:

Chronic kidney disease
Pulmonary embolism (blockage of the main artery of the lung)
Drug ineffective
Blood glucose increased
Dizziness
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Head injury
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)

male:

Death

What are the common drug interactions of Activella and Aspirin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Arrhythmia (irregular heartbeat)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Dyspnoea (difficult or laboured respiration)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Fatigue (feeling of tiredness)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Muscular weakness (muscle weakness)
Pituitary tumour benign

40-49:

Breast cancer metastatic
Metastases to meninges (cancer spreads to meninges)
Anaemia (lack of blood)
Cystitis (inflammation of the wall of the bladder)
Feeling hot
Flushing (the warm, red condition of human skin)
Haemorrhage (bleeding)
Migraine (headache)
Pruritus (severe itching of the skin)

50-59:

Folliculitis (infection of hair root)
Gastroenteritis (inflammation of stomach and intestine)
General physical health deterioration (weak health status)
Groin pain
Hypercholesterolaemia (high levels of cholesterol in the blood)
Lymphadenopathy (disease or enlargement of lymph nodes)
Malaise (a feeling of general discomfort or uneasiness)
Metastases to bone (cancer spreads to bone)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Neuropathy peripheral (surface nerve damage)

60+:

Chronic kidney disease
Pain
Bacterial test positive
Bladder irritation
Blood urine present
Chills (felling of cold)
Decreased appetite
Drug administration error
Drug effect decreased
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Pain: 15 people, 18.52%
High Blood Pressure: 15 people, 18.52%
Menopausal Symptoms: 13 people, 16.05%
Depression: 11 people, 13.58%
High Blood Cholesterol: 10 people, 12.35%
Stress And Anxiety: 8 people, 9.88%
Indigestion: 8 people, 9.88%
Infection: 7 people, 8.64%
Ill-Defined Disorder: 7 people, 8.64%
Sleep Disorder: 6 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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