Advair hfa and Oxymetazoline hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advair hfa (fluticasone propionate; salmeterol xinafoate) and Oxymetazoline hydrochloride (oxymetazoline hydrochloride). Common drug interactions include drug ineffective among females and pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Advair hfa and Oxymetazoline hydrochloride. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Advair hfa?

Advair hfa has active ingredients of fluticasone propionate; salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 69,790 Advair hfa users. Check the latest studies of Advair hfa.

What is Oxymetazoline hydrochloride?

Oxymetazoline hydrochloride has active ingredients of oxymetazoline hydrochloride. eHealthMe is studying from 594 Oxymetazoline hydrochloride users. Check the latest studies of Oxymetazoline hydrochloride.

On Jul, 13, 2026

38 people who take Advair hfa and Oxymetazoline hydrochloride together, and have interactions are studied.

Advair hfa and Oxymetazoline hydrochloride drug interactions.

What are the common drug interactions of Advair Hfa and Oxymetazoline Hydrochloride, by gender? *:

female:

Drug ineffective
Fall
Head injury
Hypersensitivity
Pain
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight increased
Fluid retention (an abnormal accumulation of fluid in the blood)
Nausea (feeling of having an urge to vomit)
Anxiety

male:

Pruritus (severe itching of the skin)
Pyrexia (fever)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Upper respiratory tract infection
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Abdominal pain upper
Asthenia (weakness)
Blood pressure fluctuation
Blood pressure systolic increased

What are the common drug interactions of Advair Hfa and Oxymetazoline Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Heart rate increased
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Nerve injury
Rales (an abnormal respiratory sound characterized by fine crackles)
Rhinorrhoea (watery mucus discharge from the nose)
Sinusitis (inflammation of sinus)
Tinnitus (a ringing in the ears)
Vocal cord paralysis

30-39:

Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Disturbance in attention
Dizziness
Presyncope

40-49:

Fluid retention (an abnormal accumulation of fluid in the blood)
Body dysmorphic disorder (type of mental illness)
Constipation
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Pneumonia
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Uterine rupture

50-59:

Abdominal pain upper
Asthenia (weakness)
Blood pressure fluctuation
Blood pressure systolic increased
Breath sounds
Bronchial wall thickening
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Calculus urethral (stone in urethra)
Chest discomfort
Choking (mechanical obstruction of the flow of air from the environment into the lungs)

60+:

Foot fracture
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dysgeusia (disorder of the sense of taste)
Emotional distress
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hand fracture
Hyperhidrosis (abnormally increased sweating)
Infection
Joint injury
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Rhinorrhea (watery mucus discharge from the nose): 10 people, 26.32%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 18.42%
Dyspnea (difficult or laboured breathing): 7 people, 18.42%
Chest Pain: 7 people, 18.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 15.79%
Drowsiness: 2 people, 5.26%
Cystic Fibrosis (disease of the secretary glands): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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