Advil and Lodine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Lodine (etodolac). Common drug interactions include autoimmune hepatitis among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Lodine. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

What is Lodine?

Lodine has active ingredients of etodolac. It is often used in pain. eHealthMe is studying from 3,846 Lodine users. Check the latest studies of Lodine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

34 people who take Advil and Lodine together, and have interactions are studied.

What are the common drug interactions of Advil and Lodine, by gender? *:

female:

Autoimmune hepatitis
Dependence
Depersonalisation
Depression
Diarrhoea
Drug addiction
Drug dependence
Drug intolerance (drug sensitivity)
Fatigue (feeling of tiredness)
Haematocrit decreased

male:

Renal failure (kidney dysfunction)
Abdominal pain upper
Hypertension (high blood pressure)
Hyperthyroidism (over activity of the thyroid gland)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Pain in extremity
Platelet aggregation increased
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Advil and Lodine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Appendicitis (inflammation of the appendix)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Chronic hepatitis (long lasting inflammation of liver)
Gastritis (inflammation of stomach)
Nausea (feeling of having an urge to vomit)
Pancreatic enzymes increased
Vomiting

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective

40-49:

Injection site rash
Injection site reaction
Injection site swelling
Injection site warmth
Nausea (feeling of having an urge to vomit)
Rash generalised (rash on most of body parts)
Rash pruritic (redness with itching)
Swollen tongue (swelling of tongue)
Vomiting
Drug hypersensitivity

50-59:

Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Autoimmune hepatitis
Chest pressure sensation (feeling of pressure on chest)
Flushing (the warm, red condition of human skin)
Haematocrit decreased
Haemoglobin decreased
Heart rate increased
Localised infection (infection at the single location)

60+:

Abdominal pain upper
Anaemia (lack of blood)
Hyperthyroidism (over activity of the thyroid gland)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Pain in extremity
Platelet aggregation increased
Renal failure (kidney dysfunction)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 23.53%
Joint Pain: 7 people, 20.59%
High Blood Cholesterol: 6 people, 17.65%
Heart Attack: 6 people, 17.65%
Depression: 6 people, 17.65%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 14.71%
Back Pain: 3 people, 8.82%
Urination - Painful: 2 people, 5.88%
Prostate Cancer: 2 people, 5.88%
Migraine (headache): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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