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Aleve and Melphalan hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Melphalan hydrochloride (melphalan hydrochloride). Common drug interactions include anhedonia among females.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Melphalan hydrochloride. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Melphalan hydrochloride?

Melphalan hydrochloride has active ingredients of melphalan hydrochloride. eHealthMe is studying from 3,970 Melphalan hydrochloride users. Check the latest studies of Melphalan hydrochloride.

On Jul, 06, 2026

12 people who take Aleve and Melphalan hydrochloride together, and have interactions are studied.

Aleve and Melphalan hydrochloride drug interactions.

What are the common drug interactions of Aleve and Melphalan Hydrochloride, by gender? *:

female:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Cough
  5. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  6. Disability
  7. Dizziness
  8. Ear infection
  9. Excoriation (to tear or wear off the skin of)
  10. Fall

male:

n/a

What are the common drug interactions of Aleve and Melphalan Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Haemophilus infection (bacterial infection by haemophilus influenzae)
  2. Hair follicle tumour benign
  3. Hyperhidrosis (abnormally increased sweating)
  4. Hypertension (high blood pressure)
  5. Hypertrophy (increase in the volume of an organ or tissue due to the enlargement of its component cells)
  6. Hypophagia (reduced food intake)
  7. Infection
  8. Injury
  9. Intervertebral disc protrusion (spinal disc protrusion)
  10. Intestinal obstruction

40-49:

n/a

50-59:

n/a

60+:

  1. Anaemia (lack of blood)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Dizziness
  4. Ear infection
  5. Excoriation (to tear or wear off the skin of)
  6. Fall
  7. Hyperglycaemia (high blood sugar)
  8. Hypoglycaemia (deficiency of glucose in the bloodstream)
  9. Injury
  10. Oral disorder (mouth disease)

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and Melphalan hydrochloride?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Aleve and Melphalan hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Melphalan hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aleve and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Melphalan hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium and melphalan hydrochloride (the active ingredients of Aleve and Melphalan hydrochloride, respectively), and Aleve and Melphalan hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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