Alrex and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alrex (loteprednol etabonate) and Simvastatin (simvastatin). Common drug interactions include femur fracture among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Alrex and Simvastatin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Alrex?

Alrex has active ingredients of loteprednol etabonate. eHealthMe is studying from 663 Alrex users. Check the latest studies of Alrex.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

27 people who take Alrex and Simvastatin together, and have interactions are studied.

Alrex and Simvastatin drug interactions.

What are the common drug interactions of Alrex and Simvastatin, by gender? *:

female:

Femur fracture
Fracture displacement
Gait disturbance
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Muscle atrophy (a decrease in the mass of the muscle)
Pain in extremity
Pathological fracture (broken bone caused by disease)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Tenderness (pain or discomfort when an affected area is touched)
Pain

male:

Anxiety
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Local swelling (swelling at the site of some application of substance or injury)
Localised infection (infection at the single location)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

What are the common drug interactions of Alrex and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)

60+:

Arthralgia (joint pain)
Femur fracture
Bone formation increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dyspepsia (indigestion)
Fall
Groin pain
Infection
Neoplasm (tumour)
Abdominal pain upper

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 22.22%
Allergies: 5 people, 18.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 14.81%
Pain: 3 people, 11.11%
Conjunctivitis (pink eye): 3 people, 11.11%
Blood Pressure Abnormal: 3 people, 11.11%
Seasonal Allergy (allergic condition due to certain season): 2 people, 7.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.41%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.41%
Osteoporosis (bones weak and more likely to break): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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