Ambien cr and Amrix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien cr (zolpidem tartrate) and Amrix (cyclobenzaprine hydrochloride). Common drug interactions include raynaud's phenomenon among females and epilepsy among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien cr and Amrix. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien cr?

Ambien cr has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 5,660 Ambien cr users. Check the latest studies of Ambien cr.

What is Amrix?

Amrix has active ingredients of cyclobenzaprine hydrochloride. It is often used in back pain. eHealthMe is studying from 1,130 Amrix users. Check the latest studies of Amrix.

On Jul, 14, 2026

11 people who take Ambien cr and Amrix together, and have interactions are studied.

What are the common drug interactions of Ambien Cr and Amrix, by gender? *:

female:

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Abdominal rigidity
Gastrointestinal infection (infection of stomach and intestine)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain
Angioedema (rapid swelling of the dermis)
Application site scar
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Memory impairment
Dry eye (lack of adequate tears)
Eye irritation
Eye swelling
Photosensitivity reaction
Sinus disorder (disease of sinus)

What are the common drug interactions of Ambien Cr and Amrix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Application site erythema (redness of the skin at application site)
Application site rash
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fungal infection
Memory impairment
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Angioedema (rapid swelling of the dermis)
Application site scar
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

50-59:

Application site rash
Fungal infection
Abdominal rigidity
Gastrointestinal infection (infection of stomach and intestine)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain
Application site erythema (redness of the skin at application site)

60+:

Dry eye (lack of adequate tears)
Eye irritation
Eye swelling
Photosensitivity reaction

What are the existing conditions these people have? *

Breakthrough Pain: 6 people, 54.55%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 54.55%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 54.55%
Pain: 6 people, 54.55%
Sleep Disorder: 6 people, 54.55%
High Blood Cholesterol: 6 people, 54.55%
Osteoporosis (bones weak and more likely to break): 5 people, 45.45%
Migraine (headache): 4 people, 36.36%
Bruxism (habitual grinding of the teeth, typically during sleep): 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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