Ambien and Alimta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien (zolpidem tartrate) and Alimta (pemetrexed disodium). Common drug interactions include rash among females and malignant neoplasm progression among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien and Alimta. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Alimta?

Alimta has active ingredients of pemetrexed disodium. eHealthMe is studying from 7,702 Alimta users. Check the latest studies of Alimta.

On Jul, 29, 2026

67 people who take Ambien and Alimta together, and have interactions are studied.

What are the common drug interactions of Ambien and Alimta, by gender? *:

female:

Rash
Chest pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Malignant neoplasm progression (cancer tumour came back)
Back pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Asthenia (weakness)
Blood alkaline phosphatase increased

male:

Malignant neoplasm progression (cancer tumour came back)
Dehydration (dryness resulting from the removal of water)
Vomiting
Constipation
Nausea (feeling of having an urge to vomit)
Anxiety
Bone disorder
Diarrhoea
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Ambien and Alimta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Bone marrow failure
Confusional state
Death
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Fatigue (feeling of tiredness)

30-39:

n/a

40-49:

n/a

50-59:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematocrit decreased
Haemoglobin decreased
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Productive cough
Vomiting
Atelectasis (partial or complete collapse of the lung)
Lymphadenopathy (disease or enlargement of lymph nodes)
Malaise (a feeling of general discomfort or uneasiness)

60+:

Back pain
Malignant neoplasm progression (cancer tumour came back)
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone fragmentation
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Brain neoplasm malignant (brain cancer tumour)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deformity (disfigurement)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 21 people, 31.34%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 10 people, 14.93%
Pain: 9 people, 13.43%
Lung Cancer Metastatic (lung cancer spreads to other parts): 8 people, 11.94%
Neoplasm Malignant (cancer tumour): 7 people, 10.45%
Lung Neoplasm Malignant (cancer tumour of lung): 7 people, 10.45%
Nausea (feeling of having an urge to vomit): 5 people, 7.46%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 5 people, 7.46%
Stress And Anxiety: 4 people, 5.97%
Constipation: 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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