Amitriptyline hydrochloride and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Aleve (naproxen sodium). Common drug interactions include pneumonia among females and bladder cancer among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Aleve. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 20, 2026

60 people who take Amitriptyline hydrochloride and Aleve together, and have interactions are studied.

Amitriptyline hydrochloride and Aleve drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Aleve, by gender? *:

female:

Pneumonia
Speech disorder
Pain in extremity
Diarrhoea
Synovial cyst (cyst of joint filled with synovial fluid)
Vomiting
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Fall

male:

Bladder cancer
Fluid retention (an abnormal accumulation of fluid in the blood)
Cardiomegaly (increased size of heart than normal)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Colon cancer
Cystitis (inflammation of the wall of the bladder)
Fatigue (feeling of tiredness)

What are the common drug interactions of Amitriptyline Hydrochloride and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Csf pressure increased
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Injury
Muscle spasms (muscle contraction)
Papilloedema (optic disc swelling)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)

40-49:

Infection
Pneumonia
Rash
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dyspnoea (difficult or laboured respiration)
Abdominal pain
Antinuclear antibody positive
Conjunctivitis (pink eye)

50-59:

Oesophageal pain
Oesophageal spasm (contraction of oesophagus)
Pneumonia
Pruritus (severe itching of the skin)
Rash
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Stomatitis (inflammation of mucous membrane of mouth)
Tinnitus (a ringing in the ears)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vision blurred

60+:

Pruritus (severe itching of the skin)
Fall
Cough
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Speech disorder
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood chloride increased

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 13 people, 21.67%
Depression: 7 people, 11.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 11.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 11.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 11.67%
Drowsiness: 6 people, 10.00%
Headache (pain in head): 5 people, 8.33%
High Blood Pressure: 4 people, 6.67%
High Blood Cholesterol: 4 people, 6.67%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Amitriptyline hydrochloride and Aleve?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously