Ancef and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ancef (cefazolin sodium) and Glucophage (metformin hydrochloride). Common drug interactions include back pain among females and injury among males.

The phase IV clinical study analyzes what interactions people have when they take Ancef and Glucophage. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Ancef?

Ancef has active ingredients of cefazolin sodium. eHealthMe is studying from 3,292 Ancef users. Check the latest studies of Ancef.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.



On Jul, 15, 2026

82 people who take Ancef and Glucophage together, and have interactions are studied.

Ancef and Glucophage drug interactions.

What are the common drug interactions of Ancef and Glucophage, by gender? *:

female:

  1. Back pain
  2. Cardiac failure congestive
  3. Cardiomegaly (increased size of heart than normal)
  4. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  5. Oedema (fluid collection in tissue)
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  7. Pneumonia
  8. Skin disorder (skin disease)
  9. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  10. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

  1. Injury
  2. Pain
  3. Death
  4. Multi-organ failure (multisystem organ failure)
  5. Depression
  6. Dyspnoea (difficult or laboured respiration)
  7. Fall
  8. Arthralgia (joint pain)
  9. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  10. Asthenia (weakness)

What are the common drug interactions of Ancef and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Injury
  3. Pain
  4. Abdominal discomfort
  5. Accident
  6. Ankle fracture
  7. Anxiety
  8. Cardiac arrest
  9. Cellulitis (infection under the skin)
  10. Circulatory collapse

50-59:

  1. Road traffic accident
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Arthralgia (joint pain)
  4. Depression
  5. Dyspnoea (difficult or laboured respiration)
  6. Fear
  7. Abdominal discomfort
  8. Ankle fracture
  9. Benign prostatic hyperplasia (benign enlargement of the prostate)
  10. Bladder spasm

60+:

  1. Pain
  2. Anxiety
  3. Death
  4. Multi-organ failure (multisystem organ failure)
  5. Depression
  6. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  7. Constipation
  8. Fall
  9. Nausea (feeling of having an urge to vomit)
  10. Confusional state

What are the existing conditions these people have? *

  1. Hypersensitivity: 16 people, 19.51%
  2. Metastatic Neoplasm (spreadable cancer tumour): 13 people, 15.85%
  3. Breast Cancer Metastatic: 13 people, 15.85%
  4. Pain: 11 people, 13.41%
  5. High Blood Pressure: 8 people, 9.76%
  6. Type 2 Diabetes: 7 people, 8.54%

* Approximation only. Some reports may have incomplete information.

Do you take Ancef and Glucophage?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ancef and Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ancef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ancef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glucophage and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on cefazolin sodium and metformin hydrochloride (the active ingredients of Ancef and Glucophage, respectively), and Ancef and Glucophage (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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