Ascorbate and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ascorbate (vitamin c (ascorbic acid)) and Ibuprofen (ibuprofen). Common drug interactions include infusion related reaction among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Ascorbate and Ibuprofen. It is created by eHealthMe based on reports of 99 people who take the same drugs from the FDA, and is updated regularly.

What is Ascorbate?

Ascorbate has active ingredients of vitamin c (ascorbic acid). eHealthMe is studying from 1,446 Ascorbate users. Check the latest studies of Ascorbate.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.



On Jul, 17, 2026

99 people who take Ascorbate and Ibuprofen together, and have interactions are studied.

Ascorbate and Ibuprofen drug interactions.

What are the common drug interactions of Ascorbate and Ibuprofen, by gender? *:

female:

  1. Infusion related reaction
  2. Liver injury
  3. Muscle spasms (muscle contraction)
  4. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
  5. Joint swelling
  6. Ear pain
  7. Impaired healing
  8. Lung disorder (lung disease)
  9. Rash
  10. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

  1. Dizziness
  2. Pyrexia (fever)
  3. Haematochezia (passage of stools containing blood)
  4. Hot flush (sudden feelings of heat)
  5. Hypersensitivity
  6. Infusion related reaction
  7. Joint swelling
  8. Throat irritation
  9. Blood pressure diastolic increased
  10. Blood pressure systolic increased

What are the common drug interactions of Ascorbate and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Dizziness
  2. Flushing (the warm, red condition of human skin)
  3. Gait disturbance
  4. Nystagmus (a condition of involuntary eye movement)
  5. Rash
  6. Vertigo

30-39:

  1. Contusion (a type of hematoma of tissue in which capillaries)
  2. Influenza like illness

40-49:

  1. Dry mouth
  2. Abdominal pain upper
  3. Drug ineffective
  4. Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
  5. Folliculitis (infection of hair root)
  6. Asthenia (weakness)
  7. Alopecia (absence of hair from areas of the body)
  8. Confusional state
  9. Deep vein thrombosis postoperative (blood clot in a major vein that usually develops in the legs and/or pelvis after operation)
  10. Abdominal discomfort

50-59:

  1. Tooth fracture
  2. Vertigo
  3. Visual impairment
  4. Vitamin d deficiency
  5. Drug ineffective
  6. Joint swelling
  7. Nausea (feeling of having an urge to vomit)
  8. Arthralgia (joint pain)
  9. Blood pressure increased
  10. Chest discomfort

60+:

  1. Osteopenia (a condition where bone mineral density is lower than normal)
  2. Osteoporosis (bones weak and more likely to break)
  3. Swelling
  4. Urinary tract infection
  5. Urticaria (rash of round, red welts on the skin that itch intensely)
  6. Weight decreased
  7. Wheezing (a high-pitched whistling sound made while you breath)
  8. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  9. Anxiety
  10. Chronic kidney disease

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 66 people, 66.67%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 53 people, 53.54%
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints): 29 people, 29.29%
  4. Stress And Anxiety: 26 people, 26.26%
  5. Psoriasis (immune-mediated disease that affects the skin): 12 people, 12.12%
  6. Migraine (headache): 9 people, 9.09%
  7. Indigestion: 8 people, 8.08%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 8.08%
  9. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 7.07%
  10. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 7.07%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ascorbate and Ibuprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ascorbate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ibuprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ascorbate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ibuprofen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on vitamin c (ascorbic acid) and ibuprofen (the active ingredients of Ascorbate and Ibuprofen, respectively), and Ascorbate and Ibuprofen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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