Avandia and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avandia (rosiglitazone maleate) and Diphen (diphenhydramine hydrochloride). Common drug interactions include chest pain among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Avandia and Diphen. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Avandia?

Avandia has active ingredients of rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 142,155 Avandia users. Check the latest studies of Avandia.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Aug, 11, 2026

66 people who take Avandia and Diphen together, and have interactions are studied.

What are the common drug interactions of Avandia and Diphen, by gender? *:

female:

Chest pain
Fall
Osteoporosis (bones weak and more likely to break)
Pleural effusion (water on the lungs)
Pneumonia
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Balance disorder
Blood homocysteine increased

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematoma (collection of blood outside the blood vessels)
Cerebellar ischaemia (lack of blood supply to cerebeller)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure acute (rapid kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the common drug interactions of Avandia and Diphen, by age (0-1 to 60+)? *:

0-1:

Balance disorder
Bradycardia (abnormally slow heart action)
Cholecystitis chronic (long lasting infection of gallbladder)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic complication
Dyspnoea (difficult or laboured respiration)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Orthopnoea (shortness of breath (dyspnea) when lying down)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Chest injury
Dysmenorrhoea (painful menstruation)
Essential hypertension (primary hypertension)
Excoriation (to tear or wear off the skin of)
Hypertension (high blood pressure)
Myositis (inflammation of the muscles)
Road traffic accident
Sternal fracture

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Balance disorder
Bradycardia (abnormally slow heart action)
Cholecystitis chronic (long lasting infection of gallbladder)
Chronic kidney disease
Diabetic complication
Dyspnoea (difficult or laboured respiration)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

50-59:

Thrombosis (formation of a blood clot inside a blood vessel)
Urinary tract infection
Cardiac arrest
Chest pain
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Respiratory failure (inadequate gas exchange by the respiratory system)
Skin ulcer
Anxiety
Aortic thrombosis (formation of a blood clot inside aorta)

60+:

Chronic kidney disease
Anaemia (lack of blood)
Cardiac arrest
Death
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 25.76%
Depression: 16 people, 24.24%
High Blood Cholesterol: 15 people, 22.73%
Pain: 13 people, 19.70%
Stress And Anxiety: 8 people, 12.12%
High Blood Pressure: 8 people, 12.12%
Multiple Allergies (allergy to multiple agents): 7 people, 10.61%
Hypersensitivity: 6 people, 9.09%
Blood Pressure Abnormal: 6 people, 9.09%
Type 2 Diabetes: 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

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