Avandia and Multihance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avandia (rosiglitazone maleate) and Multihance (gadobenate dimeglumine). Common drug interactions include nephrogenic systemic fibrosis among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Avandia and Multihance. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Avandia?

Avandia has active ingredients of rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 142,155 Avandia users. Check the latest studies of Avandia.

What is Multihance?

Multihance has active ingredients of gadobenate dimeglumine. eHealthMe is studying from 5,786 Multihance users. Check the latest studies of Multihance.



On Jul, 13, 2026

27 people who take Avandia and Multihance together, and have interactions are studied.

Avandia and Multihance drug interactions.

What are the common drug interactions of Avandia and Multihance, by gender? *:

female:

  1. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
  2. Pain
  3. Pruritus (severe itching of the skin)
  4. Skin discolouration (change of skin colour)
  5. Skin induration (an abnormally hard spot or area on the skin)
  6. Injury
  7. Joint range of motion decreased (disease of joint movement)
  8. Oedema peripheral (superficial swelling)
  9. Skin tightness
  10. Gait disturbance

male:

  1. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
  2. Skin tightness
  3. Oedema peripheral (superficial swelling)
  4. Skin fibrosis (fibrous tissue formation on skin)
  5. Skin hypertrophy (skin cells enlarges)
  6. Arthralgia (joint pain)
  7. Asthenia (weakness)
  8. Deformity (disfigurement)
  9. Depression
  10. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)

What are the common drug interactions of Avandia and Multihance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Acute myocardial infarction (acute heart attack)
  2. Angina pectoris (chest pain due to ischemia of the heart muscle)
  3. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
  4. Laryngeal oedema (swelling of larynx)
  5. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  6. Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

n/a

50-59:

  1. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
  2. Pain
  3. Skin tightness
  4. Scar
  5. Sensory loss (senses loss)
  6. Injury
  7. Anxiety
  8. Emotional distress
  9. Joint range of motion decreased (disease of joint movement)
  10. Mobility decreased (ability to move is reduced)

60+:

  1. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
  2. Skin induration (an abnormally hard spot or area on the skin)
  3. Deformity (disfigurement)
  4. Scar
  5. Skin hypertrophy (skin cells enlarges)
  6. Skin fibrosis (fibrous tissue formation on skin)
  7. Gait disturbance
  8. Pruritus (severe itching of the skin)
  9. Skin discolouration (change of skin colour)
  10. Abdominal pain upper

What are the existing conditions these people have? *

  1. Nuclear Magnetic Resonance Imaging Brain: 12 people, 44.44%
  2. Nuclear Magnetic Resonance Imaging Abdominal: 5 people, 18.52%
  3. Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 11.11%
  4. Dry Skin: 2 people, 7.41%
  5. Cardiac Failure Chronic: 2 people, 7.41%
  6. Blood Pressure Abnormal: 2 people, 7.41%
  7. Blood Phosphorus Increased: 2 people, 7.41%
  8. Anaemia (lack of blood): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Avandia and Multihance?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Avandia and Multihance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Avandia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Multihance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Avandia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Multihance and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on rosiglitazone maleate and gadobenate dimeglumine (the active ingredients of Avandia and Multihance, respectively), and Avandia and Multihance (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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