Ayvakit and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ayvakit (avapritinib) and Profen (ibuprofen). Common drug interactions include diarrhoea among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Ayvakit and Profen. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Ayvakit?

Ayvakit has active ingredients of avapritinib. eHealthMe is studying from 7,362 Ayvakit users. Check the latest studies of Ayvakit.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 15, 2026

17 people who take Ayvakit and Profen together, and have interactions are studied.

What are the common drug interactions of Ayvakit and Profen, by gender? *:

female:

Diarrhoea
Disease progression
Weight increased
Fatigue (feeling of tiredness)
Aphasia (damage to the parts of the brain that control language)
Body temperature fluctuation
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug ineffective
Hypohidrosis (lack of sweating)
Insomnia (sleeplessness)

male:

Drug hypersensitivity
Joint swelling
Eye pruritus (eye itching)
Fatigue (feeling of tiredness)
Lacrimation increased
Malaise (a feeling of general discomfort or uneasiness)
Discomfort
Headache (pain in head)
Mass
Neoplasm malignant (cancer tumour)

What are the common drug interactions of Ayvakit and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Drug hypersensitivity
Joint swelling
Memory impairment
Palpitations (feelings or sensations that your heart is pounding or racing)
Platelet count increased
Red blood cell abnormality (abnormal red blood cells)
Weight decreased

60+:

Fatigue (feeling of tiredness)
Hypokalaemia (low potassium)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Nausea (feeling of having an urge to vomit)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Vomiting
Acne (skin problems that cause pimples)
Decreased appetite

What are the existing conditions these people have? *

Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 8 people, 47.06%
Gastrointestinal Stromal Tumor: 8 people, 47.06%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 5.88%
Nausea (feeling of having an urge to vomit): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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