Azilect and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azilect (rasagiline mesylate) and Zanaflex (tizanidine hydrochloride). Common drug interactions include memory impairment among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Azilect and Zanaflex. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Azilect?

Azilect has active ingredients of rasagiline mesylate. It is often used in parkinson's disease. eHealthMe is studying from 8,622 Azilect users. Check the latest studies of Azilect.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 16, 2026

27 people who take Azilect and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Azilect and Zanaflex, by gender? *:

female:

Memory impairment
Nausea (feeling of having an urge to vomit)
Skin irritation
Delusion (a false belief or opinion)
Dyspepsia (indigestion)
Hallucination (an experience involving the perception of something not present)
Malaise (a feeling of general discomfort or uneasiness)
Thyroid disorder (thyroid diseases)
Application site dermatitis
Application site ulcer

male:

Fall
Hypertension (high blood pressure)
Hallucination (an experience involving the perception of something not present)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Osteomyelitis (infection of bone)
Pathological gambling
Presyncope
Syncope (loss of consciousness with an inability to maintain postural tone)
Arrhythmia (irregular heartbeat)
Anxiety

What are the common drug interactions of Azilect and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Application site dermatitis
Application site ulcer
Back pain
Deep brain stimulation
Device occlusion
Diarrhoea haemorrhagic (bloody diarrhoea)
Fall
Haematoma infection (infection with collection of blood outside the blood vessels)
Joint swelling
Osteomyelitis (infection of bone)

60+:

Fall
Hypertension (high blood pressure)
Dyspnoea (difficult or laboured respiration)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Incoherent (talking in a confused and unclear way)
Nervousness
Tinnitus (a ringing in the ears)
Tongue disorder (disease of tongue)
Arrhythmia (irregular heartbeat)
Hallucination (an experience involving the perception of something not present)

What are the existing conditions these people have? *

Drowsiness: 8 people, 29.63%
Pain: 7 people, 25.93%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 7.41%
Delusion (a false belief or opinion): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Azilect and Zanaflex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously