Azopt and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azopt (brinzolamide) and Zoloft (sertraline hydrochloride). Common drug interactions include dermal cyst among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Azopt and Zoloft. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Azopt?

Azopt has active ingredients of brinzolamide. It is often used in glaucoma. eHealthMe is studying from 8,058 Azopt users. Check the latest studies of Azopt.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

49 people who take Azopt and Zoloft together, and have interactions are studied.

What are the common drug interactions of Azopt and Zoloft, by gender? *:

female:

Dermal cyst
Hysterosalpingo-oophorectomy
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Nightmare (unpleasant dream)
Pruritus (severe itching of the skin)
Serum ferritin decreased
Staphylococcal infection (an infection with staphylococcus bacteria)
Vulval disorder
Vulvovaginal pruritus (vulvovaginal severe itching)
Accidental poisoning

male:

Hypertension (high blood pressure)
Pain
Lymphadenopathy (disease or enlargement of lymph nodes)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Metastases to bone (cancer spreads to bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Physical disability
Pleural effusion (water on the lungs)
Scar
Collapse of lung (functional breakdown of lung)

What are the common drug interactions of Azopt and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Enanthema (rash formed inside the body)
Pyrexia (fever)
Asthenia (weakness)
Diarrhoea
Foot amputation (loss of foot)
Lower limb fracture
Lymphoedema (localized fluid retention and tissue swelling)
Neuropathy (damage to nerves)
Neutropenia (an abnormally low number of neutrophils)
Phlebitis (inflammation of the walls of a vein)

50-59:

Emotional distress
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematuria (presence of blood in urine)
Hypertension (high blood pressure)
Infection
Injury
Intestinal resection
Lymphadenopathy (disease or enlargement of lymph nodes)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Metastases to bone (cancer spreads to bone)

60+:

Headache (pain in head)
Hypertension (high blood pressure)
Anaemia vitamin b12 deficiency
Atelectasis (partial or complete collapse of the lung)
Balance disorder
Biliary dilatation
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
Bone pain
Carcinoid syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 12.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.20%
Pain: 4 people, 8.16%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.12%
Indigestion: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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