Benzonatate and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include chest discomfort among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Isosorbide dinitrate. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 10, 2026

75 people who take Benzonatate and Isosorbide dinitrate together, and have interactions are studied.

Benzonatate and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Benzonatate and Isosorbide Dinitrate, by gender? *:

female:

Chest discomfort
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Joint range of motion decreased (disease of joint movement)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Spinal osteoarthritis (joint cartilage loss in spine)
Urinary tract infection
Abnormal faeces (abnormal stool)
Acute respiratory failure
Anxiety

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Chest pain
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Insomnia (sleeplessness)
Pain in extremity

What are the common drug interactions of Benzonatate and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Dizziness
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Vision blurred

50-59:

Nephrogenic anaemia (anaemia due to kidney disease)
Blood cholesterol increased
Blood creatinine increased
Blood triglycerides increased
Decreased activity
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pancreatitis (inflammation of pancreas)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)

60+:

Chest pain
Dyspnoea (difficult or laboured respiration)
Contusion (a type of hematoma of tissue in which capillaries)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pulmonary oedema (fluid accumulation in the lungs)
Spinal osteoarthritis (joint cartilage loss in spine)
Abnormal faeces (abnormal stool)
Aortic arteriosclerosis (hardening of the aortic arteries)
Arterial fibrosis (common cardiac arrhythmia)

What are the existing conditions these people have? *

High Blood Pressure: 29 people, 38.67%
Insomnia (sleeplessness): 26 people, 34.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 25.33%
High Blood Cholesterol: 17 people, 22.67%
Constipation: 15 people, 20.00%
Depression: 13 people, 17.33%
Diabetes: 12 people, 16.00%
Pain: 12 people, 16.00%
Fever: 11 people, 14.67%
Type 2 Diabetes: 10 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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