Brintellix and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brintellix (vortioxetine hydrobromide) and Linzess (linaclotide). Common drug interactions include insomnia among females and back disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Brintellix and Linzess. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,748 Brintellix users. Check the latest studies of Brintellix.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 26, 2026

24 people who take Brintellix and Linzess together, and have interactions are studied.

Brintellix and Linzess drug interactions.

What are the common drug interactions of Brintellix and Linzess, by gender? *:

female:

Insomnia (sleeplessness)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Diarrhoea
Fall
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Migraine (headache)
Peripheral swelling
Post-traumatic stress disorder
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Back disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Headache (pain in head)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Surgery
Urinary tract infection

What are the common drug interactions of Brintellix and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fungal infection
Vulvovaginal pruritus (vulvovaginal severe itching)

50-59:

Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Dysphonia (speech disorder attributable to a disorder of phonation)
Eating disorder
Gingivitis (inflammation of gums)
Insomnia (sleeplessness)
Lower limb fracture
Mouth ulceration (mouth ulcers)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 33.33%
High Blood Cholesterol: 4 people, 16.67%
Hypersensitivity: 4 people, 16.67%
Back Pain: 4 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
Stress And Anxiety: 4 people, 16.67%
Asthma: 4 people, 16.67%
Sleep Disorder: 4 people, 16.67%
Joint Pain: 3 people, 12.50%
Multiple Allergies (allergy to multiple agents): 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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