Calan and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Calan (verapamil hydrochloride) and Wellbutrin (bupropion hydrochloride). Common drug interactions include rheumatoid arthritis among females and chronic obstructive pulmonary disease among males.

The phase IV clinical study analyzes what interactions people have when they take Calan and Wellbutrin. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Calan?

Calan has active ingredients of verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 3,916 Calan users. Check the latest studies of Calan.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

On Jul, 11, 2026

70 people who take Calan and Wellbutrin together, and have interactions are studied.

What are the common drug interactions of Calan and Wellbutrin, by gender? *:

female:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Seborrhoea (a disease of the sebaceous glands characterized by excessive secretion of sebum)
Sinusitis (inflammation of sinus)
Blood cholesterol increased
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Dry mouth
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Infusion site swelling

male:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Essential hypertension (primary hypertension)
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gout (uric acid crystals building up in the body)
Hepatitis (inflammation of the liver)
Humerus fracture (injury to the upper arm bone)
Hyperlipidaemia (presence of excess lipids in the blood)
Joint dislocation (a joint position is changed from normal position)

What are the common drug interactions of Calan and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Arteriosclerosis (thickening and hardening of arteries)
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug ineffective
Folliculitis (infection of hair root)
Hysterectomy
Insomnia (sleeplessness)
Libido decreased (loss of interest in sex)

30-39:

Back pain
Blood cholesterol increased
Diabetes mellitus inadequate control
Enthesopathy (disorder of entheses (bone attachments))
Hyperlipidaemia (presence of excess lipids in the blood)
Joint injury
Obesity (having too much body fat)
Overweight
Type 2 diabetes mellitus

40-49:

Fall
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Blood cholesterol increased
Blood triglycerides increased
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hospitalisation
Hyperthyroidism (over activity of the thyroid gland)
Intervertebral disc disorder (spinal disc disorder)

50-59:

Heart rate increased
Hyperglycaemia (high blood sugar)
Hypertensive heart disease
Intestinal functional disorder
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Joint injury
Labile blood pressure (wildly fluctuating blood pressure)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Mitral valve incompetence (inefficient heart valve)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

60+:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gout (uric acid crystals building up in the body)
Hyperlipidaemia (presence of excess lipids in the blood)
Influenza
Pulmonary embolism (blockage of the main artery of the lung)
Lung disorder (lung disease)
Viral infection
Atypical femur fracture

What are the existing conditions these people have? *

Migraine (headache): 9 people, 12.86%
Stress And Anxiety: 6 people, 8.57%
Sleep Disorder: 6 people, 8.57%
Immunodeficiency Common Variable: 6 people, 8.57%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 7.14%
Pain: 5 people, 7.14%
High Blood Cholesterol: 5 people, 7.14%
Osteoporosis (bones weak and more likely to break): 4 people, 5.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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