Spironolactone and Metabolic alkalosis - a phase IV clinical study of FDA data

Summary:

Metabolic alkalosis is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Cardiac failure.

The phase IV clinical study analyzes which people have Metabolic alkalosis when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Metabolic alkalosis?

Metabolic alkalosis (too much bicarbonate in the blood) is found to be associated with 245 drugs and 408 conditions by eHealthMe. Check the latest studies of Metabolic alkalosis.

On Jul, 11, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 81 people (0.07%) have Metabolic alkalosis.

Could Spironolactone cause Metabolic alkalosis?

Among these 81 people:

How long have people been on Spironolactone when they have Metabolic alkalosis? *

What is the gender of people who have Metabolic alkalosis when taking Spironolactone? *

female: 62.5 %
male: 37.5 %

What is the age of people who have Metabolic alkalosis when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Metabolic alkalosis? *

Hypokalemia (low potassium): 44 people, 54.32%
Weakness: 12 people, 14.81%
Electrolyte Imbalance: 11 people, 13.58%
Oedema Peripheral (superficial swelling): 11 people, 13.58%
Rashes (redness): 10 people, 12.35%
Dehydration (dryness resulting from the removal of water): 10 people, 12.35%
Hyperglycemia (high blood sugar): 10 people, 12.35%
Lactic Acidosis (low ph in body tissues): 10 people, 12.35%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 10 people, 12.35%
Drug Ineffective: 8 people, 9.88%

What are the existing conditions these people have? *

Oedema Peripheral (superficial swelling): 12 people, 14.81%
Cardiac Failure: 12 people, 14.81%
Type 2 Diabetes: 10 people, 12.35%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 8.64%
Face Oedema (swelling of face): 7 people, 8.64%
Hypokalemia (low potassium): 7 people, 8.64%
Ascites (accumulation of fluid in the abdominal cavity): 7 people, 8.64%
Neuralgia (pain in one or more nerves): 6 people, 7.41%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 5 people, 6.17%
Diabetes: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Metabolic alkalosis?

- Check whether Metabolic alkalosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metabolic alkalosis:

Metabolic alkalosis (245 drugs)

Browse all the conditions that are associated with Metabolic alkalosis:

Metabolic alkalosis (408 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.