Cardene and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardene (nicardipine hydrochloride) and Protonix (pantoprazole sodium). Common drug interactions include hypothyroidism among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Cardene and Protonix. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Cardene?

Cardene has active ingredients of nicardipine hydrochloride. eHealthMe is studying from 729 Cardene users. Check the latest studies of Cardene.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 11, 2026

41 people who take Cardene and Protonix together, and have interactions are studied.

What are the common drug interactions of Cardene and Protonix, by gender? *:

female:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Injury
Multi-organ failure (multisystem organ failure)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Stress
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)

male:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Unresponsive to stimuli
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Abscess limb (limb infection)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aphasia (damage to the parts of the brain that control language)

What are the common drug interactions of Cardene and Protonix, by age (0-1 to 60+)? *:

0-1:

Capillary leak syndrome (capillary leaks plasma)
Hypotension (abnormally low blood pressure)

2-9:

Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)

10-19:

n/a

20-29:

Blood creatinine increased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Hypotension (abnormally low blood pressure)
Pneumomediastinum (air is present in the mediastinum)

30-39:

Breast enlargement
Menstruation irregular
Pelvic pain
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

40-49:

Abdominal pain
Anxiety
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Constipation
Cough
Drug effect decreased
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hyperkalaemia (damage to or disease of the kidney)
Hypertension (high blood pressure)

50-59:

Depression
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Anxiety
Fear
Injury
Pain
Renal impairment (severely reduced kidney function)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Blood potassium decreased
Cardiac arrest
Cheyne-stokes respiration (abnormal pattern of breathing combination of slow and faster)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)

What are the existing conditions these people have? *

Pain: 7 people, 17.07%
High Blood Pressure: 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 5 people, 12.20%
Multiple Myeloma (cancer of the plasma cells): 4 people, 9.76%
Infection: 4 people, 9.76%
Type 2 Diabetes: 3 people, 7.32%
Stress And Anxiety: 3 people, 7.32%
Hypotension (abnormally low blood pressure): 3 people, 7.32%
Fever: 3 people, 7.32%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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