Cefazolin sodium and Samsca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefazolin sodium (cefazolin sodium) and Samsca (tolvaptan). Common drug interactions include pyrexia among females and disseminated intravascular coagulation among males.

The phase IV clinical study analyzes what interactions people have when they take Cefazolin sodium and Samsca. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Cefazolin sodium?

Cefazolin sodium has active ingredients of cefazolin sodium. eHealthMe is studying from 3,649 Cefazolin sodium users. Check the latest studies of Cefazolin sodium.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

On Jul, 12, 2026

26 people who take Cefazolin sodium and Samsca together, and have interactions are studied.

Cefazolin sodium and Samsca drug interactions.

What are the common drug interactions of Cefazolin Sodium and Samsca, by gender? *:

female:

Pyrexia (fever)
Rectal prolapse (falling of rectum from normal place)
Renal impairment (severely reduced kidney function)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Viral infection
Endocarditis (inflammation in heart muscle)
Septic shock (shock due to blood infection)
Cough
Infusion site erythema (reddening of the skin at infusion site)
Infusion site haemorrhage (bleeding from infusion site)

male:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Pneumonia
Brain contusion (a form of traumatic brain injury)
Device related infection
Diarrhoea
Enteritis infectious (infection with feline parvovirus (fpv), also known as feline panleucopenia virus)
Granulocyte count decreased
Haematochezia (passage of stools containing blood)
Haematoma (collection of blood outside the blood vessels)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

What are the common drug interactions of Cefazolin Sodium and Samsca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Eosinophil count increased
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

20-29:

Oedema (fluid collection in tissue)
Pneumonia
Pruritus (severe itching of the skin)
Pubis fracture
Pyrexia (fever)
Rectal prolapse (falling of rectum from normal place)
Renal impairment (severely reduced kidney function)
Viral infection
Cough
Diarrhoea

30-39:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia (lack of blood)
Biliary colic
Device related infection
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Granulocyte count decreased
Haematochezia (passage of stools containing blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pneumonia
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)

40-49:

Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Liver disorder (liver diseases)
Pulmonary congestion (congestion in the lungs)

50-59:

Abdominal pain upper
Device related infection
Diarrhoea
Erythema (redness of the skin)
Feeling hot
Iron deficiency anaemia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Purulent discharge (discharge that contains pus)
Serratia test positive
Swelling

60+:

Endocarditis (inflammation in heart muscle)
Septic shock (shock due to blood infection)
Brain contusion (a form of traumatic brain injury)
Cardiac failure congestive
Enteritis infectious (infection with feline parvovirus (fpv), also known as feline panleucopenia virus)
Haematoma (collection of blood outside the blood vessels)
Hepatic enzyme increased
Pneumonia
Pruritus (severe itching of the skin)
Sudden death

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 30.77%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 23.08%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 19.23%
Cardiac Failure: 5 people, 19.23%
Hypokalemia (low potassium): 4 people, 15.38%
Constipation: 4 people, 15.38%
Staphylococcal Bacteraemia (a bacterial infection of blood): 3 people, 11.54%
Thrombotic Cerebral Infarction (death of cerebral tissue due to clot formation): 3 people, 11.54%
Cardiac Failure Congestive: 3 people, 11.54%
Device Related Infection: 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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