Ceftriaxone and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ceftriaxone (ceftriaxone sodium) and Sinemet (carbidopa; levodopa). Common drug interactions include colitis ulcerative among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Ceftriaxone and Sinemet. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 10, 2026

66 people who take Ceftriaxone and Sinemet together, and have interactions are studied.

Ceftriaxone and Sinemet drug interactions.

What are the common drug interactions of Ceftriaxone and Sinemet, by gender? *:

female:

Colitis ulcerative (inflammation of colon with ulcer)
Coma (state of unconsciousness lasting more than six hours)
Depressed level of consciousness
Depression
Diarrhoea
Drug hypersensitivity
Erysipelas (bacterial skin infection)
Gait disturbance
General physical health deterioration (weak health status)
Haemolytic anaemia (anaemia due to haemolysis)

male:

Fall
Dyskinesia (abnormality or impairment of voluntary movement)
Osteoporosis (bones weak and more likely to break)
Pain
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pyrexia (fever)
Weight decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased

What are the common drug interactions of Ceftriaxone and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Post procedural complication
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypercoagulation (increased tendency for clotting of the blood)
Neuralgia (pain in one or more nerves)
Suicidal ideation
Colitis (inflammation of colon)
Drug hypersensitivity
Retching (strong involuntary effort to vomit)
Skin irritation

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)

50-59:

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pyrexia (fever)
Weight decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain

60+:

Pneumonia
Cardiac failure congestive
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Coma (state of unconsciousness lasting more than six hours)
Death
Depressed level of consciousness
Depression
Diarrhoea
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Erysipelas (bacterial skin infection)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 33.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 27.27%
Drowsiness: 6 people, 9.09%
Pain: 4 people, 6.06%
Depression: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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