Cellcept and Depakote drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cellcept (mycophenolate mofetil) and Depakote (divalproex sodium). Common drug interactions include international normalised ratio increased among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Cellcept and Depakote. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Cellcept?

Cellcept has active ingredients of mycophenolate mofetil. It is often used in systemic lupus erythematosus. eHealthMe is studying from 41,872 Cellcept users. Check the latest studies of Cellcept.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

On Jul, 14, 2026

90 people who take Cellcept and Depakote together, and have interactions are studied.

Cellcept and Depakote drug interactions.

What are the common drug interactions of Cellcept and Depakote, by gender? *:

female:

International normalised ratio increased
Limb discomfort (discomfort in leg)
Loss of consciousness
Lower limb fracture
Oropharyngeal pain
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Pain
Back injury
Cardiac failure congestive
Fall
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Graft complication
Hospitalisation
Hypertensive crisis
Oxygen saturation decreased
Pleural effusion (water on the lungs)

What are the common drug interactions of Cellcept and Depakote, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Laryngitis (inflammation of the larynx)
Sinusitis (inflammation of sinus)
Back injury
Dehydration (dryness resulting from the removal of water)
Depression
Fall
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Growth hormone deficiency
Hospitalisation
Kidney transplant rejection

20-29:

Cardiac failure congestive
Pleural effusion (water on the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Migraine (headache)
Decreased appetite
Depressed level of consciousness
Diarrhoea
Disease recurrence
Local swelling (swelling at the site of some application of substance or injury)

30-39:

Blindness unilateral
Anxiety
Depression
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Arthralgia (joint pain)
Chronic kidney disease
Pancreatic disorder
Visual acuity reduced (reduced clearness of vision)

40-49:

Anxiety
Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Blood glucose decreased
Blood glucose fluctuation
Burning sensation
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Drug exposure during pregnancy
Dry skin

50-59:

Chills (felling of cold)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Disease progression
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fall
Foot fracture
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Insomnia (sleeplessness)

60+:

Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Anaemia (lack of blood)
Hypertensive crisis
International normalised ratio increased
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Oedema peripheral (superficial swelling)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Acute respiratory distress syndrome
Aphasia (damage to the parts of the brain that control language)
Balance disorder

What are the existing conditions these people have? *

Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 10 people, 11.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 6.67%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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