Clopra and Provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Provera (medroxyprogesterone acetate). Common drug interactions include hypertension among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Provera. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

On Jul, 12, 2026

84 people who take Clopra and Provera together, and have interactions are studied.

What are the common drug interactions of Clopra and Provera, by gender? *:

female:

Hypertension (high blood pressure)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Urinary tract infection
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Drug ineffective
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Impaired gastric emptying

male:

Alanine aminotransferase increased
Blood alkaline phosphatase increased
Arrhythmia (irregular heartbeat)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Asthma
Attention deficit/hyperactivity disorder
Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood albumin decreased

What are the common drug interactions of Clopra and Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Aggression
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dystonia (abnormal muscle tone)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination (an experience involving the perception of something not present)
Homicidal ideation (thoughts about human killing another human)
Insomnia (sleeplessness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)

20-29:

Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain upper
Fatigue (feeling of tiredness)
Fall
Headache (pain in head)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Rash

30-39:

Diarrhoea
Vomiting
Flatulence (flatus expelled through the anus)
Insomnia (sleeplessness)
Renal impairment (severely reduced kidney function)
Abdominal pain
Nausea (feeling of having an urge to vomit)
Anxiety
Arrhythmia (irregular heartbeat)
Blood pressure decreased

40-49:

Asthma
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cardiac failure congestive
Hyporeflexia (a condition of below normal or absent reflexes)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Sensory loss (senses loss)
Blood pressure diastolic increased
Chest pain
Cor pulmonale (enlargement of the right ventricle of the heart)

50-59:

Osteoporosis (bones weak and more likely to break)
Rib fracture
Vaginal discharge
Asthenia (weakness)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematemesis (vomiting of blood)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Muscle spasms (muscle contraction)
Pyrexia (fever)

60+:

Gamma-glutamyltransferase increased
Haematocrit decreased
Alanine aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Breast cancer
Renal failure acute (rapid kidney dysfunction)
Abdominal adhesions (inflammation of abdomen)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 20.24%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 15.48%
Nausea (feeling of having an urge to vomit): 6 people, 7.14%
Stress And Anxiety: 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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