Clozaril and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozaril (clozapine) and Naprosyn (naproxen). Common drug interactions include dysmenorrhoea among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Clozaril and Naprosyn. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Jul, 16, 2026

26 people who take Clozaril and Naprosyn together, and have interactions are studied.

Clozaril and Naprosyn drug interactions.

What are the common drug interactions of Clozaril and Naprosyn, by gender? *:

female:

Dysmenorrhoea (painful menstruation)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematemesis (vomiting of blood)
Hallucination, auditory (perceiving sounds without auditory stimulus)

male:

Pneumonia
Abdominal pain
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Delirium (wild excitement)
Lung carcinoma cell type unspecified recurrent (lung cancer reoccurrence)
Lung neoplasm malignant (cancer tumour of lung)
Metastases to bone (cancer spreads to bone)
Metastases to lung (cancer spreads to lung)

What are the common drug interactions of Clozaril and Naprosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Testis cancer (excl germ cell) (germ cell cancer of testes)

30-39:

Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coma (state of unconsciousness lasting more than six hours)
Confusion
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Dermatitis allergic (inflammation of the skin due allergic reaction)

40-49:

Abdominal pain
Abdominal tenderness
Colostomy
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Intestinal obstruction
Type 2 diabetes mellitus
Lung carcinoma cell type unspecified recurrent (lung cancer reoccurrence)
Lung neoplasm malignant (cancer tumour of lung)
Metastases to bone (cancer spreads to bone)

50-59:

Pneumonia
Confusional state
Delirium (wild excitement)
Neoplasm malignant (cancer tumour)
Pyrexia (fever)
White blood cell count decreased
Abdominal distension
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Apnoea (suspension of external breathing)
Blood glucose increased

60+:

Abdominal pain
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Intervertebral disc protrusion (spinal disc protrusion)
Lung cancer stage unspecified (exc metastatic tumours to lung) (lung cancer spreads to other parts with unspecified stage)

What are the existing conditions these people have? *

Depression: 6 people, 23.08%
Insomnia (sleeplessness): 4 people, 15.38%
Bipolar Disorder (mood disorder): 3 people, 11.54%
Sleep Disorder: 2 people, 7.69%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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