Coreg and Xywav drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coreg (carvedilol) and Xywav (calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate). Common drug interactions include dyspnoea among females and rib fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Coreg and Xywav. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Coreg?

Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.

What is Xywav?

Xywav has active ingredients of calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate. eHealthMe is studying from 7,134 Xywav users. Check the latest studies of Xywav.

On Jul, 14, 2026

26 people who take Coreg and Xywav together, and have interactions are studied.

What are the common drug interactions of Coreg and Xywav, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Nasal septum deviation (deviated nasal septum)
Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
Anxiety
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Burning sensation
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

male:

Rib fracture
Death
Dry mouth
Periodic limb movement disorder
Peripheral swelling
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)

What are the common drug interactions of Coreg and Xywav, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Angioedema (rapid swelling of the dermis)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Restless legs syndrome (a powerful urge to move your legs)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Mania (a state of abnormally elevated or irritable mood)
Nausea (feeling of having an urge to vomit)
Nerve injury
Pain
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight increased
Abdominal pain
Disability
Fall

60+:

Dry mouth
Periodic limb movement disorder
Peripheral swelling
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 100.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 23 people, 88.46%
Drowsiness: 19 people, 73.08%
Dizziness: 4 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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