Cortenema and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortenema (hydrocortisone) and Methotrexate (methotrexate sodium). Common drug interactions include drug ineffective among females and colitis ulcerative among males.

The phase IV clinical study analyzes what interactions people have when they take Cortenema and Methotrexate. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Cortenema?

Cortenema has active ingredients of hydrocortisone. eHealthMe is studying from 735 Cortenema users. Check the latest studies of Cortenema.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 17, 2026

58 people who take Cortenema and Methotrexate together, and have interactions are studied.

Cortenema and Methotrexate drug interactions.

What are the common drug interactions of Cortenema and Methotrexate, by gender? *:

female:

Drug ineffective
Colitis ulcerative (inflammation of colon with ulcer)
Dyspepsia (indigestion)
Nausea (feeling of having an urge to vomit)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Pyrexia (fever)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Procedural pain
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)

male:

Colitis ulcerative (inflammation of colon with ulcer)
Headache (pain in head)
Diarrhoea
Discomfort
Drug level decreased
Fatigue (feeling of tiredness)
Haematochezia (passage of stools containing blood)
Malaise (a feeling of general discomfort or uneasiness)
C-reactive protein increased
Lethargy (tiredness)

What are the common drug interactions of Cortenema and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Appendicitis (inflammation of the appendix)
Blood pressure decreased
C-reactive protein increased
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug dependence
Drug level below therapeutic
Fatigue (feeling of tiredness)
Feeling cold
Headache (pain in head)
Heart rate increased

20-29:

Colitis ulcerative (inflammation of colon with ulcer)
Drug level decreased
Drug ineffective
Drug level below therapeutic
Intestinal resection
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

30-39:

Colitis ulcerative (inflammation of colon with ulcer)
Arthralgia (joint pain)
Drug ineffective
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Fatigue (feeling of tiredness)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Red cell distribution width decreased
Skin disorder (skin disease)
Back pain

40-49:

n/a

50-59:

Heart rate decreased
Weight decreased

60+:

Haematochezia (passage of stools containing blood)
Dyspepsia (indigestion)
Anaemia (lack of blood)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Drug ineffective
Erythema (redness of the skin)
Female genital tract fistula (passage in genital tract of female)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 45 people, 77.59%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 25 people, 43.10%
Colitis (inflammation of colon): 13 people, 22.41%
Allergies: 13 people, 22.41%
Fever: 12 people, 20.69%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 10 people, 17.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.07%
Urethral Disorder: 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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