Cosentyx and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosentyx (secukinumab) and Zanaflex (tizanidine hydrochloride). Common drug interactions include psoriasis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Cosentyx and Zanaflex. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Cosentyx?

Cosentyx has active ingredients of secukinumab. It is often used in psoriatic arthritis. eHealthMe is studying from 187,247 Cosentyx users. Check the latest studies of Cosentyx.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 18, 2026

38 people who take Cosentyx and Zanaflex together, and have interactions are studied.

Cosentyx and Zanaflex drug interactions.

What are the common drug interactions of Cosentyx and Zanaflex, by gender? *:

female:

Psoriasis (immune-mediated disease that affects the skin)
Arthralgia (joint pain)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rash
Dyspnoea (difficult or laboured respiration)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Back pain
Syringomyelia (cavity forms within the spinal cord)
Abdominal discomfort

male:

Arthralgia (joint pain)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Spinal fusion surgery
Splenomegaly (enlargement of spleen)
Ankylosing spondylitis (type of arthritis affecting the spine)
Drug administration error
Drug ineffective
Dry eye (lack of adequate tears)
Infection

What are the common drug interactions of Cosentyx and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Back pain
Cough
Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful)
Dyspnoea (difficult or laboured respiration)
Enthesopathy (disorder of entheses (bone attachments))
Gastric ulcer (stomach ulcer)
Joint stiffness

40-49:

Drug hypersensitivity
Drug ineffective
Hypersensitivity
Psoriasis (immune-mediated disease that affects the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Drug intolerance (drug sensitivity)

50-59:

Abdominal distension
Ankylosing spondylitis (type of arthritis affecting the spine)
Back pain
Chronic inflammatory demyelinating polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord)
Discomfort
Drug ineffective
Local swelling (swelling at the site of some application of substance or injury)
Psoriasis (immune-mediated disease that affects the skin)
Pulmonary embolism (blockage of the main artery of the lung)
Rash

60+:

Dyspnoea (difficult or laboured respiration)
Local swelling (swelling at the site of some application of substance or injury)
Mobility decreased (ability to move is reduced)
Rash
Vomiting
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Diarrhoea

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 12 people, 31.58%
Psoriasis (immune-mediated disease that affects the skin): 9 people, 23.68%
Pain: 7 people, 18.42%
Nausea (feeling of having an urge to vomit): 3 people, 7.89%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 7.89%
Sleep Disorder: 2 people, 5.26%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.26%
Hypersensitivity: 2 people, 5.26%
High Blood Pressure: 2 people, 5.26%
Depression: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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