Cosopt and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Zoloft (sertraline hydrochloride). Common drug interactions include colon cancer among females and bacteraemia among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Zoloft. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 12, 2026

66 people who take Cosopt and Zoloft together, and have interactions are studied.

What are the common drug interactions of Cosopt and Zoloft, by gender? *:

female:

Colon cancer
Confusional state
Death
Dementia (madness)
Dry mouth
Erythema of eyelid (redness of the eyelid)
Eyelids pruritus (eyelids itching)
Fracture
Gait disturbance
Head discomfort

male:

Bacteraemia (presence of bacteria in the blood)
Dehydration (dryness resulting from the removal of water)
Cellulitis (infection under the skin)
Chronic kidney disease
Death
Eye haemorrhage (bleeding in the eye)
Eye pain
Fatigue (feeling of tiredness)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypervolaemia (abnormally increased volume of blood)

What are the common drug interactions of Cosopt and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Dry skin

30-39:

n/a

40-49:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Dysphoria (generalized dissatisfaction with life)
Gallbladder injury
Injection site pain
Oropharyngeal discomfort (pain or irritation of oropharynx)
Palpitations (feelings or sensations that your heart is pounding or racing)
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

Hypotension (abnormally low blood pressure)
Impaired gastric emptying
Implant site infection
Lethargy (tiredness)
Myopia (difficult to see objects that are far away)
Nausea (feeling of having an urge to vomit)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal failure (kidney dysfunction)
Septic shock (shock due to blood infection)
Vomiting

60+:

Confusional state
Delusion (a false belief or opinion)
Bacteraemia (presence of bacteria in the blood)
Blood glucose increased
Death
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Gingival bleeding (bleeding gums)
Gingival hypertrophy (overgrowth of gums)

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 10.61%
High Blood Cholesterol: 7 people, 10.61%
Diabetes: 6 people, 9.09%
Osteoporosis (bones weak and more likely to break): 5 people, 7.58%
Stress And Anxiety: 4 people, 6.06%
Pain: 4 people, 6.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.06%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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