Creon and Guaifenesin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Creon (pancrelipase (amylase;lipase;protease)) and Guaifenesin (guaifenesin). Common drug interactions include constipation among females and sputum increased among males.

The phase IV clinical study analyzes what interactions people have when they take Creon and Guaifenesin. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Guaifenesin?

Guaifenesin has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 12,106 Guaifenesin users. Check the latest studies of Guaifenesin.

On Jul, 06, 2026

81 people who take Creon and Guaifenesin together, and have interactions are studied.

Creon and Guaifenesin drug interactions.

What are the common drug interactions of Creon and Guaifenesin, by gender? *:

female:

Constipation
Drug hypersensitivity
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Ear infection
Ear pain
Gingival pain (gum pain)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)

male:

Sputum increased
Dyspnoea (difficult or laboured respiration)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Night sweats (sweating in night)
Productive cough
Pruritus (severe itching of the skin)
Pseudomonas test positive
Pyrexia (fever)
Secretion discharge
Sputum discoloured

What are the common drug interactions of Creon and Guaifenesin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cystic fibrosis (disease of the secretary glands)
Sputum increased
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Headache (pain in head)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pyrexia (fever)

20-29:

n/a

30-39:

Pyrexia (fever)
Asthenia (weakness)
Chest discomfort
Chest pain
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

40-49:

Anxiety
Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone pain
Chronic kidney disease
Decreased activity
Depression
Dizziness
Fatigue (feeling of tiredness)

50-59:

Mobility decreased (ability to move is reduced)
Nerve compression
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Abdominal discomfort
Asthenia (weakness)
Blood glucose increased

60+:

Fatigue (feeling of tiredness)
Pneumonia
Cardiac disorder
Constipation
Decreased appetite
Drug hypersensitivity
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Ear infection
Ear pain

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 27 people, 33.33%
Nausea (feeling of having an urge to vomit): 17 people, 20.99%
Pain: 14 people, 17.28%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 17.28%
Rickets (softening of bones): 13 people, 16.05%
Stress And Anxiety: 12 people, 14.81%
Constipation: 10 people, 12.35%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 9 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 11.11%
Muscle Spasms (muscle contraction): 9 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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