Creon and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Creon (pancrelipase (amylase;lipase;protease)) and Zanaflex (tizanidine hydrochloride). Common drug interactions include urinary tract infection among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Creon and Zanaflex. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Aug, 04, 2026

83 people who take Creon and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Creon and Zanaflex, by gender? *:

female:

Urinary tract infection
Fatigue (feeling of tiredness)
Weight decreased
Asthenia (weakness)
Diarrhoea
Fall
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia
Headache (pain in head)
Syncope (loss of consciousness with an inability to maintain postural tone)

male:

Anxiety
Disability
Nausea (feeling of having an urge to vomit)
Pancreatitis relapsing
Dyspepsia (indigestion)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Abdominal pain
Cataract (clouding of the lens inside the eye)
Death
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

What are the common drug interactions of Creon and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal distension
Colonic obstruction (obstruction in colon)
Dry skin
Gingivitis (inflammation of gums)
Headache (pain in head)
Oral herpes (viral infection of mouth)
Rash
Volvulus (obstruction caused by twisting of the stomach or intestine)
Death
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

40-49:

Dizziness
Hepatic steatosis (fatty liver disease)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal pain
Chest pain
Diarrhoea
Nausea (feeling of having an urge to vomit)
Anxiety
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)

50-59:

Arthralgia (joint pain)
Back pain
Depression
Diarrhoea
Gait disturbance
Headache (pain in head)
Insomnia (sleeplessness)
Neck pain
Neuropathy peripheral (surface nerve damage)
Pain in extremity

60+:

Urinary tract infection
Asthenia (weakness)
Herpes zoster
Infusion site bruising
Infusion site swelling
Neoplasm malignant (cancer tumour)
Pancreatic carcinoma (pancreatic cancer)
Anaesthetic complication
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood pressure decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 25.30%
Pain: 17 people, 20.48%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 18.07%
Fibromyalgia (a long-term condition which causes pain all over the body): 14 people, 16.87%
Immunodeficiency Common Variable: 12 people, 14.46%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 12.05%
Stress And Anxiety: 8 people, 9.64%
Nausea (feeling of having an urge to vomit): 8 people, 9.64%
Insomnia (sleeplessness): 8 people, 9.64%
Constipation: 8 people, 9.64%

* Approximation only. Some reports may have incomplete information.

Do you take Creon and Zanaflex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously