Cymbalta and Tikosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cymbalta (duloxetine hydrochloride) and Tikosyn (dofetilide). Common drug interactions include pain among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Cymbalta and Tikosyn. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

What is Tikosyn?

Tikosyn has active ingredients of dofetilide. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 12,202 Tikosyn users. Check the latest studies of Tikosyn.

On Aug, 09, 2026

58 people who take Cymbalta and Tikosyn together, and have interactions are studied.

What are the common drug interactions of Cymbalta and Tikosyn, by gender? *:

female:

Pain
Pain in extremity
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pyrexia (fever)
Rash
Renal failure (kidney dysfunction)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Septic shock (shock due to blood infection)
Sinus disorder (disease of sinus)

male:

Dizziness
Abnormal dreams
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cyst (a closed sac)
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)
Haemorrhage (bleeding)
Intervertebral disc protrusion (spinal disc protrusion)

What are the common drug interactions of Cymbalta and Tikosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspepsia (indigestion)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pain

40-49:

Memory impairment
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Oesophageal spasm (contraction of oesophagus)
Oesophageal ulcer (ulcer of oesophagus)
Pallor
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Blood glucose increased
Blood pressure decreased

50-59:

Diarrhoea
Flushing (the warm, red condition of human skin)
Dyspepsia (indigestion)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Blood creatinine decreased
Blood pressure decreased

60+:

Insomnia (sleeplessness)
Drug ineffective
Antibiotic therapy
Asthenia (weakness)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Syncope (loss of consciousness with an inability to maintain postural tone)
Suicidal ideation
Arthralgia (joint pain)
Blood glucose increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 12.07%
High Blood Pressure: 7 people, 12.07%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 10.34%
Pain: 6 people, 10.34%
Diabetes: 6 people, 10.34%
Type 2 Diabetes: 5 people, 8.62%
Neuropathy Peripheral (surface nerve damage): 5 people, 8.62%
Multiple Myeloma (cancer of the plasma cells): 5 people, 8.62%
Drowsiness: 4 people, 6.90%
Back Pain: 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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