Daytrana and Seroquel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daytrana (methylphenidate) and Seroquel (quetiapine fumarate). Common drug interactions include nerve root injury lumbar among females and heart rate increased among males.

The phase IV clinical study analyzes what interactions people have when they take Daytrana and Seroquel. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Daytrana?

Daytrana has active ingredients of methylphenidate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 16,561 Daytrana users. Check the latest studies of Daytrana.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.

On Jul, 19, 2026

69 people who take Daytrana and Seroquel together, and have interactions are studied.

Daytrana and Seroquel drug interactions.

What are the common drug interactions of Daytrana and Seroquel, by gender? *:

female:

Nerve root injury lumbar (nerve root injury at the lumber vertebra)
Osteomyelitis (infection of bone)
Overdose
Restless legs syndrome (a powerful urge to move your legs)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Sialoadenitis (inflammation of a salivary gland)
Skin candida (fungal infection of skin)
Skin ulcer
Tooth abscess (pus formation in tooth)

male:

Heart rate increased
Application site erythema (redness of the skin at application site)
Foot fracture
Hydrocephalus (water on the brain)
Migraine (headache)
Stress
Tibia fracture (fracture of lower leg bone)
Application site pruritus (application site severe itching of the skin)
Blood pressure increased
Body temperature increased

What are the common drug interactions of Daytrana and Seroquel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective
Application site erythema (redness of the skin at application site)
Blood glucose decreased
Delirium (wild excitement)
Dissociative disorder
Fatigue (feeling of tiredness)
Inflammatory carcinoma of the breast
Leukopenia (less number of white blood cells in blood)
Metastases to muscle (cancer spreads to muscle)
Nausea (feeling of having an urge to vomit)

10-19:

Hypertriglyceridaemia (excess of triglycerides in the blood)
Intervertebral discitis (infection in the intervertebral disc space)
Lethargy (tiredness)
Mood altered (changes in mood)
Nerve root injury lumbar (nerve root injury at the lumber vertebra)
Osteomyelitis (infection of bone)
Restless legs syndrome (a powerful urge to move your legs)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Sialoadenitis (inflammation of a salivary gland)
Skin candida (fungal infection of skin)

20-29:

Blood pressure increased
Body temperature increased
Dizziness
Drug effect decreased
Feeling drunk
Heart rate increased
Nervousness

30-39:

Application site erythema (redness of the skin at application site)
Application site burn
Application site dryness
Application site oedema
Application site pruritus (application site severe itching of the skin)
Application site rash
Application site vesicles (small bubble within a cell at application site)

40-49:

Craniocerebral injury (injury to cranium and brain)
Mental disability
Aspergillosis (an infection caused by a fungus called aspergillus)
Chills (felling of cold)
Citrobacter infection (infection by citrobacter (bacteria))
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Escherichia infection (bacterial infection by escherichia coli)
Haematuria (presence of blood in urine)
Heart rate increased

50-59:

Agitation (state of anxiety or nervous excitement)
Chest pain
Confusional state
Drug ineffective
Hyperglycaemia (high blood sugar)
Nightmare (unpleasant dream)
Rash
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 7.25%
Agitation (state of anxiety or nervous excitement): 5 people, 7.25%

* Approximation only. Some reports may have incomplete information.

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