Daytrana and Tenex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daytrana (methylphenidate) and Tenex (guanfacine hydrochloride). Common drug interactions include drug ineffective among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Daytrana and Tenex. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Daytrana?

Daytrana has active ingredients of methylphenidate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 16,561 Daytrana users. Check the latest studies of Daytrana.

What is Tenex?

Tenex has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,865 Tenex users. Check the latest studies of Tenex.

On Jul, 21, 2026

62 people who take Daytrana and Tenex together, and have interactions are studied.

What are the common drug interactions of Daytrana and Tenex, by gender? *:

female:

Drug ineffective
Hypersensitivity
Stubbornness (dark personality traits)
Overdose
Application site erythema (redness of the skin at application site)
Application site scab (hard coating on the skin formed at application site)
Drug administration error
Insomnia (sleeplessness)
Weight decreased

male:

Drug ineffective
Application site erythema (redness of the skin at application site)
Adverse drug reaction
Aggression
Anger
Application site erosion
Application site rash
Application site swelling
Application site urticaria
Burning sensation

What are the common drug interactions of Daytrana and Tenex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective
Application site erosion
Application site scab (hard coating on the skin formed at application site)
Disturbance in attention
Disturbance in social behaviour
Ileus (a painful obstruction of the ileum or other part of the intestine)
Insomnia (sleeplessness)
Pneumonia
Psychomotor hyperactivity (feelings of extreme restlessness)
Strabismus (a disorder in which the two eyes do not line up in the same direction)

10-19:

Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Aggression
Application site rash
Application site swelling
Application site urticaria
Drug ineffective
Intentional self-injury
Nephrolithiasis (calculi in the kidneys)
Suicidal ideation

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Overdose

60+:

n/a

What are the existing conditions these people have? *

Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 6 people, 9.68%
Impulsive Behavior: 6 people, 9.68%
Hypersensitivity: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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