Depo-provera and Levothroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depo-provera (medroxyprogesterone acetate) and Levothroid (levothyroxine sodium). Common drug interactions include hyperkinetic syndrome among females and abdominal adhesions among males.

The phase IV clinical study analyzes what interactions people have when they take Depo-provera and Levothroid. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

On Jul, 20, 2026

13 people who take Depo-provera and Levothroid together, and have interactions are studied.

Depo-provera and Levothroid drug interactions.

What are the common drug interactions of Depo-Provera and Levothroid, by gender? *:

female:

Hyperkinetic syndrome (attention deficit disorder)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Impaired gastric emptying
Insomnia (sleeplessness)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura)
Lordosis (outward curve of the back bone)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Mania (a state of abnormally elevated or irritable mood)

male:

Abdominal adhesions (inflammation of abdomen)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Attention deficit/hyperactivity disorder
Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood glucose fluctuation
Cardiolipin antibody positive
Cerebellar ataxia (loss of coordination)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Depo-Provera and Levothroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Depression
Migraine (headache)
Ovarian cyst ruptured (tear in fluid filled sac of the ovary)
Ovarian torsion (twisting of ovary)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)

30-39:

Blood cholesterol increased
Type 2 diabetes mellitus

40-49:

Drug eruption (adverse drug reaction of the skin)
Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura)
Oral soft tissue disorder (oral soft tissue disease)
Rash generalised (rash on most of body parts)
Skin lesion
Swelling face
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Fall
Mydriasis (a dilation of the pupil)
Depression
Dyspnoea (difficult or laboured respiration)
Swelling face

60+:

Abdominal adhesions (inflammation of abdomen)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Attention deficit/hyperactivity disorder
Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood glucose fluctuation
Breast cancer
Cardiolipin antibody positive
Cerebellar ataxia (loss of coordination)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the existing conditions these people have? *

Neuropathy Peripheral (surface nerve damage): 2 people, 15.38%
Impaired Gastric Emptying: 2 people, 15.38%
High Blood Pressure: 2 people, 15.38%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 2 people, 15.38%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 15.38%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.69%
Pain: 1 person, 7.69%
Menopausal Symptoms: 1 person, 7.69%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 7.69%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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