Digoxin and Alkeran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Digoxin (digoxin) and Alkeran (melphalan). Common drug interactions include mitral valve incompetence among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Digoxin and Alkeran. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

What is Alkeran?

Alkeran has active ingredients of melphalan. eHealthMe is studying from 5,429 Alkeran users. Check the latest studies of Alkeran.



On Jul, 12, 2026

21 people who take Digoxin and Alkeran together, and have interactions are studied.

Digoxin and Alkeran drug interactions.

What are the common drug interactions of Digoxin and Alkeran, by gender? *:

female:

  1. Mitral valve incompetence (inefficient heart valve)
  2. Mitral valve prolapse (heart's mitral valve doesn't work well)
  3. Monoclonal gammopathy
  4. Multiple injuries
  5. Multiple myeloma (cancer of the plasma cells)
  6. Muscle spasms (muscle contraction)
  7. Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
  8. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  9. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
  10. Nervousness

male:

  1. Anaemia (lack of blood)
  2. Cystitis haemorrhagic (blood in the urine and painful voiding)
  3. Haemolytic anaemia (anaemia due to haemolysis)
  4. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  5. Plasma cell myeloma (cancer that begins in plasma cells)
  6. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  7. C-reactive protein increased
  8. Cellulitis (infection under the skin)
  9. Constipation
  10. Disease progression

What are the common drug interactions of Digoxin and Alkeran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Anaemia (lack of blood)
  2. Constipation
  3. Death
  4. Fatigue (feeling of tiredness)
  5. Haemoglobin decreased
  6. Platelet count decreased
  7. Pyrexia (fever)
  8. Ventricular fibrillation (abnormally irregular heart rhythm)
  9. Abasia (inability to walk)
  10. Abdominal pain

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 13 people, 61.90%
  2. Arrhythmias (irregular heartbeat): 5 people, 23.81%
  3. Stable Angina (a constant chest pain): 3 people, 14.29%
  4. Pain: 3 people, 14.29%
  5. Lumbar Vertebral Fracture: 3 people, 14.29%
  6. High Blood Pressure: 3 people, 14.29%
  7. Gastritis (inflammation of stomach): 3 people, 14.29%
  8. Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 2 people, 9.52%
  9. Stress And Anxiety: 2 people, 9.52%
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Digoxin and Alkeran?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Digoxin and Alkeran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Digoxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Alkeran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Digoxin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Alkeran and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on digoxin and melphalan (the active ingredients of Digoxin and Alkeran, respectively), and Digoxin and Alkeran (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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