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Divalproex and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Macrobid. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 09, 2026

25 people who take Divalproex and Macrobid together, and have interactions are studied.

Divalproex and Macrobid drug interactions.

What are the common drug interactions of Divalproex and Macrobid, by gender? *:

female:

  1. Anxiety
  2. Rash
  3. Abdominal discomfort
  4. Insomnia (sleeplessness)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Mobility decreased (ability to move is reduced)
  7. Blood prolactin increased
  8. Cellulitis (infection under the skin)
  9. Conjunctivitis (pink eye)
  10. Dyspepsia (indigestion)

male:

n/a

What are the common drug interactions of Divalproex and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Alanine aminotransferase increased
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Anxiety
  4. Aspartate aminotransferase increased
  5. Bile duct stone
  6. Cholecystitis chronic (long lasting infection of gallbladder)
  7. Culture urine positive
  8. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  9. Electrocardiogram qt prolonged
  10. Emotional distress

30-39:

  1. Anxiety
  2. Fibromyalgia (a long-term condition which causes pain all over the body)
  3. Mania (a state of abnormally elevated or irritable mood)
  4. Neuropathy peripheral (surface nerve damage)
  5. Renal failure (kidney dysfunction)
  6. Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
  7. Chronic kidney disease

40-49:

  1. Weight decreased
  2. Abdominal discomfort
  3. Abdominal pain upper
  4. Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
  5. Agitation (state of anxiety or nervous excitement)
  6. Anxiety
  7. Back pain
  8. Blood prolactin increased
  9. Bone neoplasm (tumour of bone)
  10. Breast cancer recurrent

50-59:

  1. Anxiety disorder
  2. Arthralgia (joint pain)
  3. Asthenia (weakness)
  4. Atrophy (wasting away of a part of the body)
  5. Back pain
  6. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  7. Contusion (a type of hematoma of tissue in which capillaries)
  8. Depression
  9. Fall
  10. Insomnia (sleeplessness)

60+:

  1. Constipation
  2. Aggression
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  5. Oxygen saturation decreased
  6. Pallor
  7. Swelling face
  8. Blood lactic acid increased
  9. Confusional state
  10. Dysarthria (speech disorder)

What are the existing conditions these people have? *

  1. Pain: 5 people, 20.00%
  2. Immunodeficiency Common Variable: 5 people, 20.00%
  3. Stress And Anxiety: 4 people, 16.00%
  4. Sleep Disorder: 3 people, 12.00%
  5. Itching: 3 people, 12.00%
  6. High Blood Pressure: 3 people, 12.00%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 12.00%
  9. Parkinson's Disease: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex and Macrobid?

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- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Divalproex and Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Divalproex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Divalproex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Macrobid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium and nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Divalproex and Macrobid, respectively), and Divalproex and Macrobid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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