Droxidopa and Entacapone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Droxidopa (droxidopa) and Entacapone (entacapone). Common drug interactions include abdominal pain among females and irritability among males.

The phase IV clinical study analyzes what interactions people have when they take Droxidopa and Entacapone. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Droxidopa?

Droxidopa has active ingredients of droxidopa. eHealthMe is studying from 1,093 Droxidopa users. Check the latest studies of Droxidopa.

What is Entacapone?

Entacapone has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 4,261 Entacapone users. Check the latest studies of Entacapone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

33 people who take Droxidopa and Entacapone together, and have interactions are studied.

Droxidopa and Entacapone drug interactions.

What are the common drug interactions of Droxidopa and Entacapone, by gender? *:

female:

Abdominal pain
Dyskinesia (abnormality or impairment of voluntary movement)
Gastrointestinal ulcer
Intussusception
Pneumonia
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Camptocormia (abnormal posture of the trunk)
Death
Decreased appetite
Dehydration (dryness resulting from the removal of water)

male:

Irritability
Agitation (state of anxiety or nervous excitement)
Dyskinesia (abnormality or impairment of voluntary movement)
Fall
Jealous delusion (false belief sexual partner is not faithful)
Weight decreased
Abdominal injury
Adverse drug reaction
Back pain
Bezoar (mass found trapped in the gastrointestinal system)

What are the common drug interactions of Droxidopa and Entacapone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Agitation (state of anxiety or nervous excitement)
Confusional state
Fear
Mania (a state of abnormally elevated or irritable mood)
Irritability
Overdose
Abdominal pain
Dyskinesia (abnormality or impairment of voluntary movement)
Gastrointestinal ulcer
Intussusception

60+:

Aggression
Anxiety
Abdominal injury
Adverse drug reaction
Back pain
Bezoar (mass found trapped in the gastrointestinal system)
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Depression
General physical health deterioration (weak health status)
Hospitalisation

What are the existing conditions these people have? *

Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 7 people, 21.21%
Dementia With Lewy Bodies (progressive degenerative disease or syndrome of the brain): 5 people, 15.15%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 6.06%
Freezing Phenomenon: 2 people, 6.06%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 6.06%
Delusion (a false belief or opinion): 2 people, 6.06%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 2 people, 6.06%
Behavioral And Psychiatric Symptoms Of Dementia: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Droxidopa and Entacapone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously