Echinacea and Vitamin d3 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Echinacea (echinacea) and Vitamin d3 (cholecalciferol). Common drug interactions include dizziness among females and pulmonary embolism among males.

The phase IV clinical study analyzes what interactions people have when they take Echinacea and Vitamin d3. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Echinacea?

Echinacea has active ingredients of echinacea. It is often used in immune response. eHealthMe is studying from 1,930 Echinacea users. Check the latest studies of Echinacea.

What is Vitamin d3?

Vitamin d3 has active ingredients of cholecalciferol. It is often used in heart health. eHealthMe is studying from 32,176 Vitamin d3 users. Check the latest studies of Vitamin d3.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

68 people who take Echinacea and Vitamin d3 together, and have interactions are studied.

Echinacea and Vitamin d3 drug interactions.

What are the common drug interactions of Echinacea and Vitamin D3, by gender? *:

female:

Dizziness
Drug ineffective
Dysuria (painful or difficult urination)
Headache (pain in head)
Hyperaesthesia
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness
Injection site pain
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

male:

Pulmonary embolism (blockage of the main artery of the lung)
Sleep disorder
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Infection
Influenza

What are the common drug interactions of Echinacea and Vitamin D3, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Injection site pain

20-29:

Asthma
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle spasms (muscle contraction)
Pain
Panic reaction
Ulcer
Anxiety
Arthralgia (joint pain)

30-39:

Fatigue (feeling of tiredness)
Abnormal behaviour
Anxiety
Bipolar disorder (mood disorder)
Borderline personality disorder
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Gait disturbance
Influenza like illness

40-49:

Diarrhoea
Fatigue (feeling of tiredness)
Pain
Pain in extremity
Swelling
Abdominal pain
Abdominal pain upper
Accommodation disorder
Angioedema (rapid swelling of the dermis)
Asthenia (weakness)

50-59:

Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Migraine (headache)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Thrombosis (formation of a blood clot inside a blood vessel)
Ulcer haemorrhage (bleeding ulcer)
Vomiting
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Back pain
Chronic kidney disease
Influenza
Nephrogenic anaemia (anaemia due to kidney disease)
Pain
Pneumonia
Pruritus (severe itching of the skin)
Pulmonary embolism (blockage of the main artery of the lung)

What are the existing conditions these people have? *

Stress And Anxiety: 9 people, 13.24%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 11.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.29%
Multiple Myeloma (cancer of the plasma cells): 7 people, 10.29%
Sleep Disorder: 6 people, 8.82%
Pain: 6 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.82%
Hypersensitivity: 5 people, 7.35%
Cardiac Disorder: 5 people, 7.35%
Prostate Cancer Metastatic: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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