Efudex and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Efudex (fluorouracil) and Simvastatin (simvastatin). Common drug interactions include abdominal discomfort among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Efudex and Simvastatin. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

On Jul, 10, 2026

48 people who take Efudex and Simvastatin together, and have interactions are studied.

Efudex and Simvastatin drug interactions.

What are the common drug interactions of Efudex and Simvastatin, by gender? *:

female:

Abdominal discomfort
Chest pain
Gastritis (inflammation of stomach)
Neoplasm malignant (cancer tumour)
Pain
Abdominal distension
Abdominal pain upper
Adnexa uteri mass (ovarian cysts)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

male:

Pneumonia
Road traffic accident
Rash macular (small, flat red spots)
Skin burning sensation
Abdominal distension
Adverse event
Anaemia (lack of blood)
Anxiety
Anxiety disorder
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)

What are the common drug interactions of Efudex and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Small intestinal obstruction (blockage in small intestine)

50-59:

Productive cough
Psychological trauma
Chronic kidney disease
Renal failure (kidney dysfunction)
Alopecia (absence of hair from areas of the body)
Hair colour changes
Alopecia areata (patchy baldness that typically begins with rapid hair loss)
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Hair disorder

60+:

Pneumonia
Road traffic accident
Asthenia (weakness)
Cholecystitis chronic (long lasting infection of gallbladder)
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)
Haemoglobin decreased
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Hypotension (abnormally low blood pressure)
Pain

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 11 people, 22.92%
Multiple Myeloma (cancer of the plasma cells): 9 people, 18.75%
Breast Cancer Female: 8 people, 16.67%
Pain: 3 people, 6.25%
Metastases To Bone (cancer spreads to bone): 3 people, 6.25%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Efudex and Simvastatin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously