Epiduo and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epiduo (adapalene; benzoyl peroxide) and Ibuprofen (ibuprofen). Common drug interactions include rash among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Epiduo and Ibuprofen. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Epiduo?

Epiduo has active ingredients of adapalene; benzoyl peroxide. It is often used in acne. eHealthMe is studying from 1,581 Epiduo users. Check the latest studies of Epiduo.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

49 people who take Epiduo and Ibuprofen together, and have interactions are studied.

What are the common drug interactions of Epiduo and Ibuprofen, by gender? *:

female:

Rash
Cellulitis (infection under the skin)
Fatigue (feeling of tiredness)
Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Apnoea (suspension of external breathing)
Chest discomfort
Discomfort
Therapeutic response unexpected
Depressed mood

male:

Drug ineffective
Therapeutic response unexpected
Constipation
Dry eye (lack of adequate tears)
Optic neuropathy (optic nerve damage)
Tremor (trembling or shaking movements in one or more parts of your body)
Drug intolerance (drug sensitivity)
Decreased appetite
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)

What are the common drug interactions of Epiduo and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anaphylactic reaction (serious allergic reaction)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Hypersensitivity
Optic neuropathy (optic nerve damage)
Rash
Retinal degeneration (death of the cells of the retina)
Retinal tear
Sleep disorder
Therapeutic response unexpected

20-29:

Drug ineffective
Constipation
Dry eye (lack of adequate tears)
Stress
Muscle spasms (muscle contraction)
Therapeutic response unexpected
Fatigue (feeling of tiredness)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)

30-39:

Asthma
Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Oropharyngeal pain
Pain in extremity
Pneumonia
Rash

40-49:

Therapeutic response unexpected

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Emotional distress
Renal impairment (severely reduced kidney function)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 29 people, 59.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 27 people, 55.10%
Muscle Twitching: 15 people, 30.61%
Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 10 people, 20.41%
Drowsiness: 7 people, 14.29%
Muscle Spasms (muscle contraction): 5 people, 10.20%
Ill-Defined Disorder: 4 people, 8.16%
Birth Control: 4 people, 8.16%
Stress And Anxiety: 3 people, 6.12%
Dry Eyes (lack of adequate tears): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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