Epivir and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epivir (lamivudine) and Simvastatin (simvastatin). Common drug interactions include renal impairment among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Epivir and Simvastatin. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Epivir?

Epivir has active ingredients of lamivudine. It is often used in hiv infection. eHealthMe is studying from 16,870 Epivir users. Check the latest studies of Epivir.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

On Jul, 17, 2026

83 people who take Epivir and Simvastatin together, and have interactions are studied.

Epivir and Simvastatin drug interactions.

What are the common drug interactions of Epivir and Simvastatin, by gender? *:

female:

Renal impairment (severely reduced kidney function)
Anaemia (lack of blood)
Bone loss
Femur fracture
Gait disturbance
Mobility decreased (ability to move is reduced)
Bedridden
Bone pain
Depression
Fibula fracture

male:

Pain
Renal failure (kidney dysfunction)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrolithiasis (calculi in the kidneys)
Renal transplant
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Decreased activity
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Impaired work ability

What are the common drug interactions of Epivir and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Paraesthesia circumoral (morbid or perverted sensation; an abnormal sensation, as burning, prickling, formication etc)
Hypoaesthesia (reduced sense of touch or sensation)
Pancreatitis (inflammation of pancreas)
Peripheral neuropathy (damage to nerves of the peripheral nervous system)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Renal disorder (kidney disease)
Visual acuity reduced (reduced clearness of vision)

30-39:

Osteopenia (a condition where bone mineral density is lower than normal)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone pain
Decreased activity
Emotional distress
Mobility decreased (ability to move is reduced)
Multiple fractures
Osteoporosis (bones weak and more likely to break)

40-49:

Emotional distress
Pain
Renal failure (kidney dysfunction)
Anxiety
Renal impairment (severely reduced kidney function)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Nephrolithiasis (calculi in the kidneys)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Decreased activity
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Balance disorder
Blood potassium decreased
Breath sounds
Cough
Creatinine urine increased
Dysarthria (speech disorder)
Dysuria (painful or difficult urination)
Gait disturbance
Heart rate decreased

60+:

Emotional distress
Pain
Renal impairment (severely reduced kidney function)
Blood creatinine increased
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Osteopenia (a condition where bone mineral density is lower than normal)
Alanine aminotransferase increased
Ankle fracture
Aspartate aminotransferase increased
Blood alkaline phosphatase increased

What are the existing conditions these people have? *

Hiv Infection: 47 people, 56.63%
Pain: 14 people, 16.87%
Diabetes: 13 people, 15.66%
Depression: 9 people, 10.84%
High Blood Pressure: 8 people, 9.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.64%
Nuclear Magnetic Resonance Imaging Brain: 6 people, 7.23%

* Approximation only. Some reports may have incomplete information.

Do you take Epivir and Simvastatin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously