Estradiol and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estradiol (estradiol) and Actos (pioglitazone hydrochloride). Common drug interactions include mental disorder among females and abscess limb among males.

The phase IV clinical study analyzes what interactions people have when they take Estradiol and Actos. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 13, 2026

28 people who take Estradiol and Actos together, and have interactions are studied.

What are the common drug interactions of Estradiol and Actos, by gender? *:

female:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multiple fractures
Neuropathy (damage to nerves)
Nipple exudate bloody (discharge from nipple with blood)
Onychoclasis (breaking of the nails)
Osteopenia (a condition where bone mineral density is lower than normal)
Overdose
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Pyrexia (fever)

male:

Abscess limb (limb infection)
Cellulitis (infection under the skin)
Pain
Perineal abscess
Perirectal abscess
Rectal abscess (pus in rectum)
Renal failure (kidney dysfunction)
Scar
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Estradiol and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Multiple fractures
Nausea (feeling of having an urge to vomit)
Necrosis (the death of body tissue)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nerve injury
Osteopenia (a condition where bone mineral density is lower than normal)
Palpitations (feelings or sensations that your heart is pounding or racing)
Perineal abscess
Perirectal abscess
Pneumonia

50-59:

Drug ineffective
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anxiety
Application site discolouration
Application site irritation

60+:

Fall
Depression
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cystitis (inflammation of the wall of the bladder)
Diabetes mellitus inadequate control
Dizziness
Dysphonia (speech disorder attributable to a disorder of phonation)
Eating disorder

What are the existing conditions these people have? *

Type 2 Diabetes: 9 people, 32.14%
Pain: 5 people, 17.86%
Depression: 4 people, 14.29%
Sleep Disorder: 2 people, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.14%
Rashes (redness): 2 people, 7.14%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 7.14%
Nausea (feeling of having an urge to vomit): 2 people, 7.14%
High Blood Pressure: 2 people, 7.14%
High Blood Cholesterol: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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