Etodolac and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Etodolac (etodolac) and Zanaflex (tizanidine hydrochloride). Common drug interactions include gait disturbance among females and neck pain among males.

The phase IV clinical study analyzes what interactions people have when they take Etodolac and Zanaflex. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Etodolac?

Etodolac has active ingredients of etodolac. It is often used in arthritis. eHealthMe is studying from 9,157 Etodolac users. Check the latest studies of Etodolac.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 19, 2026

93 people who take Etodolac and Zanaflex together, and have interactions are studied.

Etodolac and Zanaflex drug interactions.

What are the common drug interactions of Etodolac and Zanaflex, by gender? *:

female:

Gait disturbance
Cough
Dizziness
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash
Asthma
Ataxia (loss of full control of bodily movements)
Balance disorder
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Confusional state

male:

Neck pain
Arthralgia (joint pain)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Erythema (redness of the skin)
Foramen magnum stenosis (opening is not large enough for the spinal cord to easily pass)
Gait disturbance
Gingival bleeding (bleeding gums)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoxia (low oxygen in tissues)
Impaired healing

What are the common drug interactions of Etodolac and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Neck pain
Back pain
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Back disorder
Bone disorder
Cardiovascular disorder (heart diseases)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dry mouth
Dyspepsia (indigestion)

40-49:

Arthralgia (joint pain)
Colitis (inflammation of colon)
Disturbance in attention
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Joint range of motion decreased (disease of joint movement)
Knee arthroplasty
Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Peroneal nerve palsy

50-59:

Pain in extremity
Rash pruritic (redness with itching)
Swelling face
Vision blurred
Abnormal dreams
Blood pressure fluctuation
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cough
Depression
Diarrhoea

60+:

Asthenia (weakness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Confusional state
Cough
Depression
Diplopia (double vision)
Dizziness
Dry mouth
Dry skin
Dysstasia (difficulty in standing)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 28 people, 30.11%
Pain: 27 people, 29.03%
Gait Disturbance: 21 people, 22.58%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 17.20%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 16.13%
Osteoporosis (bones weak and more likely to break): 14 people, 15.05%
Cough: 14 people, 15.05%
Urethritis Noninfective (inflammation of the urethra - non infective): 13 people, 13.98%
Blood Glucose Abnormal: 12 people, 12.90%
Bladder Disorder: 11 people, 11.83%

* Approximation only. Some reports may have incomplete information.

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